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Optics Letters

Optics Letters


  • Editor: Alan E. Willner
  • Vol. 35, Iss. 13 — Jul. 1, 2010
  • pp: 2127–2129

Ultrasonic enhancement of photoacoustic emissions by nanoparticle-targeted cavitation

James R. McLaughlan, Ronald A. Roy, Hengyi Ju, and Todd W. Murray  »View Author Affiliations

Optics Letters, Vol. 35, Issue 13, pp. 2127-2129 (2010)

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A technique to enhance the photoacoustic emissions from laser-heated nanoparticles is presented. Gold nano particle-doped phantoms are subjected to pulsed optical and ultrasound fields, resulting in bubble formation and collapse and producing strong acoustic emissions. The applied ultrasound field allows for cavitation at lower laser fluences than using light alone. The acoustic emission associated with bubble collapse well exceeds the direct photoacoustic response and is used to image a nanoparticle-doped region in a tissue phantom. The strong acoustic emission and low-threshold fluence associated with ultrasound-assisted cavitation make the technique well suited for nanoparticle-targeted biological imaging and tissue therapy.

© 2010 Optical Society of America

OCIS Codes
(170.5120) Medical optics and biotechnology : Photoacoustic imaging
(170.7170) Medical optics and biotechnology : Ultrasound
(140.3945) Lasers and laser optics : Microcavities
(110.5125) Imaging systems : Photoacoustics

ToC Category:
Medical Optics and Biotechnology

Original Manuscript: March 5, 2010
Revised Manuscript: May 14, 2010
Manuscript Accepted: May 25, 2010
Published: June 16, 2010

Virtual Issues
Vol. 5, Iss. 11 Virtual Journal for Biomedical Optics

James R. McLaughlan, Ronald A. Roy, Hengyi Ju, and Todd W. Murray, "Ultrasonic enhancement of photoacoustic emissions by nanoparticle-targeted cavitation," Opt. Lett. 35, 2127-2129 (2010)

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