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Optics Letters

| RAPID, SHORT PUBLICATIONS ON THE LATEST IN OPTICAL DISCOVERIES

  • Editor: Alan E. Willner
  • Vol. 35, Iss. 16 — Aug. 15, 2010
  • pp: 2771–2773

Label-free biosensor array based on silicon-on-insulator ring resonators addressed using a WDM approach

D.-X. Xu, M. Vachon, A. Densmore, R. Ma, A. Delâge, S. Janz, J. Lapointe, Y. Li, G. Lopinski, D. Zhang, Q. Y. Liu, P. Cheben, and J. H. Schmid  »View Author Affiliations


Optics Letters, Vol. 35, Issue 16, pp. 2771-2773 (2010)
http://dx.doi.org/10.1364/OL.35.002771


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Abstract

We report a silicon-on-insulator ring resonator biosensor array with one output port, using wavelength division multiplexing as the addressing scheme. With the use of on-chip referencing for environmental drift cancellation, simultaneous monitoring of multiplexed molecular bindings is demonstrated, with a resolution of 0.3 pg / mm 2 ( 40 ag of total mass) for protein concentrations over 4 orders of magnitude down to 20 pM . Reactions are measured over time periods as long as 3 h with high stability.

OCIS Codes
(120.0120) Instrumentation, measurement, and metrology : Instrumentation, measurement, and metrology
(130.3120) Integrated optics : Integrated optics devices
(130.6010) Integrated optics : Sensors
(230.5750) Optical devices : Resonators

ToC Category:
Integrated Optics

History
Original Manuscript: June 4, 2010
Manuscript Accepted: June 24, 2010
Published: August 13, 2010

Virtual Issues
Vol. 5, Iss. 13 Virtual Journal for Biomedical Optics

Citation
D.-X. Xu, M. Vachon, A. Densmore, R. Ma, A. Delâge, S. Janz, J. Lapointe, Y. Li, G. Lopinski, D. Zhang, Q. Y. Liu, P. Cheben, and J. H. Schmid, "Label-free biosensor array based on silicon-on-insulator ring resonators addressed using a WDM approach," Opt. Lett. 35, 2771-2773 (2010)
http://www.opticsinfobase.org/ol/abstract.cfm?URI=ol-35-16-2771


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References

  1. A. Densmore, M. Vachon, D.-X. Xu, S. Janz, R. Ma, Y.-H. Li, G. Lopinski, A. Delâge, J. Lapointe, C. C. Luebbert, Q. Y. Liu, P. Cheben, and J. H. Schmid, Opt. Lett. 34, 3598 (2009). [CrossRef] [PubMed]
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