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Optics Letters

| RAPID, SHORT PUBLICATIONS ON THE LATEST IN OPTICAL DISCOVERIES

  • Editor: Alan E. Willner
  • Vol. 35, Iss. 17 — Sep. 1, 2010
  • pp: 2840–2842

Spatial-domain low-coherence quantitative phase microscopy for cancer diagnosis

Pin Wang, Rajan Bista, Rohit Bhargava, Randall E. Brand, and Yang Liu  »View Author Affiliations


Optics Letters, Vol. 35, Issue 17, pp. 2840-2842 (2010)
http://dx.doi.org/10.1364/OL.35.002840


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Abstract

A microscopy technique, spatial-domain low-coherence quantitative phase microscopy (SL-QPM) is proposed for speckle-free, quantitative phase imaging of subcellular structures with subnanometer sensitivity. We quantified, for the first time to our knowledge, the refractive index of the cell nuclei on original unmodified histology specimens. We demonstrate that the refractive index of cell nucleus is highly sensitive in detecting cancer, especially in histologically normal-appearing cells from cancer patients. Because this technique is sensitive and does not require special sample processing, it can be disseminated to all clinical settings.

© 2010 Optical Society of America

OCIS Codes
(110.0180) Imaging systems : Microscopy
(120.3180) Instrumentation, measurement, and metrology : Interferometry
(170.4580) Medical optics and biotechnology : Optical diagnostics for medicine
(290.1350) Scattering : Backscattering

ToC Category:
Imaging Systems

History
Original Manuscript: May 27, 2010
Revised Manuscript: July 19, 2010
Manuscript Accepted: July 19, 2010
Published: August 17, 2010

Virtual Issues
Vol. 5, Iss. 13 Virtual Journal for Biomedical Optics

Citation
Pin Wang, Rajan Bista, Rohit Bhargava, Randall E. Brand, and Yang Liu, "Spatial-domain low-coherence quantitative phase microscopy for cancer diagnosis," Opt. Lett. 35, 2840-2842 (2010)
http://www.opticsinfobase.org/ol/abstract.cfm?URI=ol-35-17-2840


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