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Optics Letters

Optics Letters


  • Editor: Alan E. Willner
  • Vol. 35, Iss. 22 — Nov. 15, 2010
  • pp: 3751–3753

Utility of biodegradable plasmonic nanoclusters in photoacoustic imaging

Soon Joon Yoon, Srivalleesha Mallidi, Jasmine M. Tam, Justina O. Tam, Avinash Murthy, Keith P. Johnston, Konstantin V. Sokolov, and Stanislav Y. Emelianov  »View Author Affiliations

Optics Letters, Vol. 35, Issue 22, pp. 3751-3753 (2010)

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Plasmonic metal nanoparticles are used in photoacoustic imaging as contrast agents because of their resonant optical absorption properties in the visible and near-IR regions. However, the nanoparticles could accumulate and result in long-term toxicity in vivo, because they are generally not biodegradable. Recently, biodegradable plasmonic gold nanoclusters, consisting of sub- 5 nm primary gold nanoparticles and biodegradable polymer stabilizer, were introduced. In this Letter, we demonstrate the feasibility of biodegradable nanoclusters as a photoacoustic contrast agent. We performed photoacoustic and ultrasound imaging of a tissue-mimicking phantom with inclusions containing nanoclusters at various concentrations. The results indicate that the biodegradable gold nanoclusters can be used as effective contrast agents in photoacoustic imaging.

© 2010 Optical Society of America

OCIS Codes
(110.5120) Imaging systems : Photoacoustic imaging
(110.7170) Imaging systems : Ultrasound
(170.3880) Medical optics and biotechnology : Medical and biological imaging

ToC Category:
Medical Optics and Biotechnology

Original Manuscript: August 13, 2010
Manuscript Accepted: September 20, 2010
Published: November 3, 2010

Virtual Issues
Vol. 6, Iss. 1 Virtual Journal for Biomedical Optics

Soon Joon Yoon, Srivalleesha Mallidi, Jasmine M. Tam, Justina O. Tam, Avinash Murthy, Keith P. Johnston, Konstantin V. Sokolov, and Stanislav Y. Emelianov, "Utility of biodegradable plasmonic nanoclusters in photoacoustic imaging," Opt. Lett. 35, 3751-3753 (2010)

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