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Optics Letters

Optics Letters


  • Editor: Alan E. Willner
  • Vol. 35, Iss. 22 — Nov. 15, 2010
  • pp: 3838–3840

Microlens array recording of localized retinal responses

Qiu-Xiang Zhang, Jin-Yu Wang, Lei Liu, and Xin-Cheng Yao  »View Author Affiliations

Optics Letters, Vol. 35, Issue 22, pp. 3838-3840 (2010)

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We designed a rapid functional imager for the parallel recording of localized intrinsic optical signals (IOSs). This imager used a microlens array (MLA)-based illuminator to deliver visible stimulus light and near-infrared (NIR) recording light simultaneously. The parfocal configuration of the stimulus and recording light illumination enabled confocal recording of the stimulus-evoked IOSs. Because the MLA stimulation/recording spots were widely separated on the retina, and only the photoreceptors within the MLA stimulation/recording spots were stimulated, the potential IOS cross talk effect among neighboring retinal areas was minimized. Our experiments revealed robust IOS activities tightly correlated with localized retinal responses.

© 2010 Optical Society of America

OCIS Codes
(330.4270) Vision, color, and visual optics : Vision system neurophysiology
(330.5310) Vision, color, and visual optics : Vision - photoreceptors
(170.2655) Medical optics and biotechnology : Functional monitoring and imaging

ToC Category:
Medical Optics and Biotechnology

Original Manuscript: July 27, 2010
Revised Manuscript: October 4, 2010
Manuscript Accepted: October 15, 2010
Published: November 12, 2010

Virtual Issues
Vol. 6, Iss. 1 Virtual Journal for Biomedical Optics

Qiu-Xiang Zhang, Jin-Yu Wang, Lei Liu, and Xin-Cheng Yao, "Microlens array recording of localized retinal responses," Opt. Lett. 35, 3838-3840 (2010)

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  1. J. Schallek, H. Li, R. Kardon, Y. Kwon, M. Abramoff, P. Soliz, and D. Ts’o, Invest. Ophthalmol. Vis. Sci. 50, 4865 (2009). [CrossRef] [PubMed]
  2. G. Hanazono, K. Tsunoda, K. Shinoda, K. Tsubota, Y. Miyake, and M. Tanifuji, Invest. Ophthalmol. Vis. Sci. 48, 2903 (2007). [CrossRef] [PubMed]
  3. R. S. Jonnal, J. Rha, Y. Zhang, B. Cense, W. H. Gao, and D. T. Miller, Opt. Express 15, 16141 (2007). [CrossRef] [PubMed]
  4. K. Grieve and A. Roorda, Invest. Ophthalmol. Vis. Sci. 49, 713 (2008). [CrossRef] [PubMed]
  5. J. Rha, B. Schroeder, P. Godara, and J. Carroll, Opt. Lett. 34, 3782 (2009). [CrossRef] [PubMed]
  6. X. C. Yao, A. Yamauchi, B. Perry, and J. S. George, Appl. Opt. 44, 2019 (2005). [CrossRef] [PubMed]
  7. K. Bizheva, R. Pflug, B. Hermann, B. Povazay, H. Sattmann, P. Qiu, E. Anger, H. Reitsamer, S. Popov, J. R. Taylor, A. Unterhuber, P. Ahnelt, and W. Drexler, Proc. Natl. Acad. Sci. USA 103, 5066 (2006). [CrossRef] [PubMed]
  8. V. J. Srinivasan, M. Wojtkowski, J. G. Fujimoto, and J. S. Duker, Opt. Lett. 31, 2308 (2006). [CrossRef] [PubMed]
  9. T. Schmoll, C. Kolbitsch, and R. A. Leitgeb, J. Biomed. Opt. 15041513 (2010). [CrossRef] [PubMed]
  10. Y. C. Li, C. Strang, F. R. Amthor, L. Liu, Y. G. Li, Q. X. Zhang, K. Keyser, and X. C. Yao, Opt. Lett. 35, 1810 (2010). [CrossRef] [PubMed]
  11. X. C. Yao and Y. B. Zhao, Opt. Express 16, 12446 (2008). [CrossRef] [PubMed]
  12. Y. G. Li, L. Liu, F. Amthor, and X. C. Yao, Opt. Lett. 35, 426 (2010). [CrossRef] [PubMed]
  13. X. C. Yao and Y. B. Zhao, Opt. Express 16, 12446 (2008). [CrossRef] [PubMed]
  14. K. P. Hofmann, R. Uhl, W. Hoffmann, and W. Kreutz, Biophys. Struct. Mech. 2, 61 (1976). [CrossRef] [PubMed]
  15. H. Kuhn, N. Bennett, M. Michel-Villaz, and M. Chabre, Proc. Natl. Acad. Sci. USA 78, 6873 (1981). [CrossRef] [PubMed]
  16. V. Y. Arshavsky, T. D. Lamb, and E. N. Pugh, Jr., Ann. Rev. Physiol. 64, 153 (2002). [CrossRef]

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