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Optics Letters

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  • Editor: Alan E. Willner
  • Vol. 35, Iss. 23 — Dec. 1, 2010
  • pp: 3889–3891

On the potential for molecular imaging with Cerenkov luminescence

Matthew A. Lewis, Vikram D. Kodibagkar, Orhan K. Öz, and Ralph P. Mason  »View Author Affiliations


Optics Letters, Vol. 35, Issue 23, pp. 3889-3891 (2010)
http://dx.doi.org/10.1364/OL.35.003889


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Abstract

Recent observation of optical luminescence due to beta decay from suitable radiotracers has led to the possible development of new preclinical optical imaging methods. The generation of photons that can be detected using instrumentation optimized for bioluminescence imaging has been putatively associated with the Cerenkov effect. We describe the simultaneous utilization of fluorescence reporters to convert Cerenkov luminescence to longer wavelengths for better tissue penetration and also for modulating the luminescence spectrum for potential molecular imaging strategies.

© 2010 Optical Society of America

OCIS Codes
(170.3880) Medical optics and biotechnology : Medical and biological imaging
(260.3800) Physical optics : Luminescence
(170.2655) Medical optics and biotechnology : Functional monitoring and imaging

ToC Category:
Medical Optics and Biotechnology

History
Original Manuscript: September 1, 2010
Revised Manuscript: October 25, 2010
Manuscript Accepted: October 27, 2010
Published: November 18, 2010

Citation
Matthew A. Lewis, Vikram D. Kodibagkar, Orhan K. Öz, and Ralph P. Mason, "On the potential for molecular imaging with Cerenkov luminescence," Opt. Lett. 35, 3889-3891 (2010)
http://www.opticsinfobase.org/ol/abstract.cfm?URI=ol-35-23-3889


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