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Optics Letters

| RAPID, SHORT PUBLICATIONS ON THE LATEST IN OPTICAL DISCOVERIES

  • Editor: Alan E. Willner
  • Vol. 35, Iss. 3 — Feb. 1, 2010
  • pp: 270–272

Photoacoustic ocular imaging

Adam de la Zerda, Yannis M. Paulus, Robert Teed, Sunil Bodapati, Yosh Dollberg, Butrus T. Khuri-Yakub, Mark S. Blumenkranz, Darius M. Moshfeghi, and Sanjiv Sam Gambhir  »View Author Affiliations


Optics Letters, Vol. 35, Issue 3, pp. 270-272 (2010)
http://dx.doi.org/10.1364/OL.35.000270


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Abstract

We developed a photoacoustic ocular imaging device and demonstrated its utility in imaging the deeper layers of the eye including the retina, choroid, and optic nerve. Using safe laser intensity, the photoacoustic system was able to visualize the blood distribution of an enucleated pig’s eye and an eye of a living rabbit. Ultrasound images, which were simultaneously acquired, were overlaid on the photoacoustic images to visualize the eye’s anatomy. Such a system may be used in the future for early detection and improved management of neovascular ocular diseases, including wet age-related macular degeneration and proliferative diabetic retinopathy.

© 2010 Optical Society of America

OCIS Codes
(110.5120) Imaging systems : Photoacoustic imaging
(110.7170) Imaging systems : Ultrasound
(170.4460) Medical optics and biotechnology : Ophthalmic optics and devices

ToC Category:
Medical Optics and Biotechnology

History
Original Manuscript: October 5, 2009
Revised Manuscript: December 6, 2009
Manuscript Accepted: December 7, 2009
Published: January 20, 2010

Virtual Issues
Vol. 5, Iss. 4 Virtual Journal for Biomedical Optics

Citation
Adam de la Zerda, Yannis M. Paulus, Robert Teed, Sunil Bodapati, Yosh Dollberg, Butrus T. Khuri-Yakub, Mark S. Blumenkranz, Darius M. Moshfeghi, and Sanjiv Sam Gambhir, "Photoacoustic ocular imaging," Opt. Lett. 35, 270-272 (2010)
http://www.opticsinfobase.org/ol/abstract.cfm?URI=ol-35-3-270


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References

  1. D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and J. G. Fujimoto, Science 254, 1178 (1991). [CrossRef] [PubMed]
  2. S. W. Kang, C. Y. Park, and D. I. Ham, Am. J. Ophthalmol. 137, 313 (2004). [CrossRef] [PubMed]
  3. P. E. Stanga, J. I. Lim, and P. Hamilton, Ophthalmology 110, 15 (2003). [CrossRef] [PubMed]
  4. R. H. Silverman, Clin. Exp. Ophthalmol. 37, 54 (2009). [CrossRef]
  5. R. F. Spaide, D. Armstrong, and R. Browne, Retina 23, 595 (2003). [CrossRef] [PubMed]
  6. M. H. Xu and L. H. V. Wang, Rev. Sci. Instrum. 77, 041101 (2006). [CrossRef]
  7. H. F. Zhang, K. Maslov, G. Stoica, and L. V. Wang, Nat. Biotechnol. 24, 848 (2006). [CrossRef] [PubMed]
  8. J. Laufer, E. Zhang, G. Raivich, and P. Beard, Appl. Opt. 48, D299 (2009). [CrossRef] [PubMed]
  9. J. T. Oh, M. L. Li, H. F. Zhang, K. Maslov, G. Stoica, and L. V. Wang, J. Biomed. Opt. 11, 034032 (2006). [CrossRef]
  10. A. de la Zerda, C. Zavaleta, S. Keren, S. Vaithilingam, S. Bodapati, Z. Liu, J. Levi, B. R. Smith, T. J. Ma, O. Oralkan, Z. Cheng, X. Chen, H. Dai, B. T. Khuri-Yakub, and S. S. Gambhir, Nat. Nanotechnol. 3, 557 (2008). [CrossRef] [PubMed]
  11. American National Standards Institute, American National Standard for the Safe Use of Lasers: ANSI Standard Z136.1-2000 (ANSI, Inc., 2000).
  12. Z. Xie, S. Jiao, H. F. Zhang, and C. A. Puliafito, Opt. Lett. 34, 1771 (2009). [CrossRef] [PubMed]

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