Comparison of fluorescence tomographic imaging in mice with early-arriving and quasi-continuous-wave photons
Optics Letters, Vol. 35, Issue 3, pp. 369-371 (2010)
http://dx.doi.org/10.1364/OL.35.000369
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Abstract
The highly diffuse nature of light propagation in biological tissue is a major challenge for obtaining high-fidelity fluorescence tomographic images. In this work we investigated the use of time-gated detection of early-arriving photons for reducing the effects of light scatter in mice relative to quasi-cw photons. When analyzing sinographic representations of the measured data, it was determined that early photons allowed a reduction in the measured FWHM of fluorescent targets by a factor of approximately 2–3, yielding a significant improvement in the tomographic image reconstruction quality.
© 2010 Optical Society of America
OCIS Codes
(170.6920) Medical optics and biotechnology : Time-resolved imaging
(300.2530) Spectroscopy : Fluorescence, laser-induced
(110.6955) Imaging systems : Tomographic imaging
ToC Category:
Medical Optics and Biotechnology
History
Original Manuscript: October 2, 2009
Revised Manuscript: November 20, 2009
Manuscript Accepted: November 21, 2009
Published: January 27, 2010
Virtual Issues
Vol. 5, Iss. 4 Virtual Journal for Biomedical Optics
Citation
Mark Niedre and Vasilis Ntziachristos, "Comparison of fluorescence tomographic imaging in mice with early-arriving and quasi-continuous-wave photons," Opt. Lett. 35, 369-371 (2010)
http://www.opticsinfobase.org/ol/abstract.cfm?URI=ol-35-3-369
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