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Optics Letters

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  • Editor: Alan E. Willner
  • Vol. 35, Iss. 3 — Feb. 1, 2010
  • pp: 369–371

Comparison of fluorescence tomographic imaging in mice with early-arriving and quasi-continuous-wave photons

Mark Niedre and Vasilis Ntziachristos  »View Author Affiliations


Optics Letters, Vol. 35, Issue 3, pp. 369-371 (2010)
http://dx.doi.org/10.1364/OL.35.000369


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Abstract

The highly diffuse nature of light propagation in biological tissue is a major challenge for obtaining high-fidelity fluorescence tomographic images. In this work we investigated the use of time-gated detection of early-arriving photons for reducing the effects of light scatter in mice relative to quasi-cw photons. When analyzing sinographic representations of the measured data, it was determined that early photons allowed a reduction in the measured FWHM of fluorescent targets by a factor of approximately 2–3, yielding a significant improvement in the tomographic image reconstruction quality.

© 2010 Optical Society of America

OCIS Codes
(170.6920) Medical optics and biotechnology : Time-resolved imaging
(300.2530) Spectroscopy : Fluorescence, laser-induced
(110.6955) Imaging systems : Tomographic imaging

ToC Category:
Medical Optics and Biotechnology

History
Original Manuscript: October 2, 2009
Revised Manuscript: November 20, 2009
Manuscript Accepted: November 21, 2009
Published: January 27, 2010

Virtual Issues
Vol. 5, Iss. 4 Virtual Journal for Biomedical Optics

Citation
Mark Niedre and Vasilis Ntziachristos, "Comparison of fluorescence tomographic imaging in mice with early-arriving and quasi-continuous-wave photons," Opt. Lett. 35, 369-371 (2010)
http://www.opticsinfobase.org/ol/abstract.cfm?URI=ol-35-3-369


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References

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