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Optics Letters

Optics Letters


  • Editor: Alan E. Willner
  • Vol. 35, Iss. 3 — Feb. 1, 2010
  • pp: 429–431

Development of a compensation algorithm for accurate depth localization in diffuse optical tomography

Haijing Niu, Fenghua Tian, Zi-Jing Lin, and Hanli Liu  »View Author Affiliations

Optics Letters, Vol. 35, Issue 3, pp. 429-431 (2010)

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Diffuse optical tomography endures poor depth localization, since its sensitivity decreases severely with increased depth. In this study, we demonstrate a depth compensation algorithm (DCA), which optimally counterbalances the decay nature of light propagation in tissue so as to accurately localize absorbers in deep tissue. The novelty of DCA is to directly modify the sensitivity matrix, rather than the penalty term of regularization. DCA is based on maximum singular values (MSVs) of layered measurement sensitivities; these MSVs are inversely utilized to create a balancing weight matrix for compensating the measurement sensitivity in increased depth. Both computer simulations and laboratory experiments were performed to validate DCA. These results demonstrate that one (or two) 3-cm-deep absorber(s) can be accurately located in both lateral plane and depth within the laboratorial position errors.

© 2010 Optical Society of America

OCIS Codes
(170.3010) Medical optics and biotechnology : Image reconstruction techniques
(170.5280) Medical optics and biotechnology : Photon migration
(170.6960) Medical optics and biotechnology : Tomography

ToC Category:
Medical Optics and Biotechnology

Original Manuscript: September 24, 2009
Revised Manuscript: December 21, 2009
Manuscript Accepted: December 23, 2009
Published: January 29, 2010

Virtual Issues
Vol. 5, Iss. 4 Virtual Journal for Biomedical Optics

Haijing Niu, Fenghua Tian, Zi-Jing Lin, and Hanli Liu, "Development of a compensation algorithm for accurate depth localization in diffuse optical tomography," Opt. Lett. 35, 429-431 (2010)

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