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Optics Letters

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  • Editor: Alan E. Willner
  • Vol. 35, Iss. 7 — Apr. 1, 2010
  • pp: 1109–1111

Cerenkov luminescence tomography for small-animal imaging

Changqing Li, Gregory S. Mitchell, and Simon R. Cherry  »View Author Affiliations


Optics Letters, Vol. 35, Issue 7, pp. 1109-1111 (2010)
http://dx.doi.org/10.1364/OL.35.001109


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Abstract

Cerenkov radiation is a well-known phenomenon in which optical photons are emitted by charged particles moving faster than the speed of light in a medium. We have observed Cerenkov photons emitted from β-emitting radiotracers such as F 18 -fluorodeoxyglucose using a sensitive CCD camera. Phantom and in vivo mouse imaging experiments have demonstrated that surface measurements of the emitted Cerenkov optical photons could be used to reconstruct the radiotracer activity distribution inside an object by modeling the optical photon propagation with the diffusion equation and reconstructing the optical emission source distribution iteratively with a preconditioned conjugate gradient method.

© 2010 Optical Society of America

OCIS Codes
(170.3880) Medical optics and biotechnology : Medical and biological imaging
(170.6960) Medical optics and biotechnology : Tomography
(170.2655) Medical optics and biotechnology : Functional monitoring and imaging

ToC Category:
Medical Optics and Biotechnology

History
Original Manuscript: November 10, 2009
Revised Manuscript: February 22, 2010
Manuscript Accepted: February 25, 2010
Published: March 31, 2010

Virtual Issues
Vol. 5, Iss. 8 Virtual Journal for Biomedical Optics

Citation
Changqing Li, Gregory S. Mitchell, and Simon R. Cherry, "Cerenkov luminescence tomography for small-animal imaging," Opt. Lett. 35, 1109-1111 (2010)
http://www.opticsinfobase.org/ol/abstract.cfm?URI=ol-35-7-1109


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References

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