OSA's Digital Library

Optics Letters

Optics Letters


  • Editor: Alan E. Willner
  • Vol. 35, Iss. 9 — May. 1, 2010
  • pp: 1314–1316

Deep-tissue imaging of intramolecular fluorescence resonance energy-transfer parameters

Vaibhav Gaind, Sumith Kularatne, Philip S. Low, and Kevin J. Webb  »View Author Affiliations

Optics Letters, Vol. 35, Issue 9, pp. 1314-1316 (2010)

View Full Text Article

Enhanced HTML    Acrobat PDF (338 KB)

Browse Journals / Lookup Meetings

Browse by Journal and Year


Lookup Conference Papers

Close Browse Journals / Lookup Meetings

Article Tools



We demonstrate the in vivo reconstruction of all fluorescence resonance energy transfer (FRET) parameters, including the nanometer donor–acceptor distance, in a mouse. The FRET chemical targets cancer cells, and on internalization, the acceptor is released, in lieu of a targeted anticancer drug in chemotherapy. Our method provides a new vehicle for studying disease by imaging FRET parameters in deep tissue.

© 2010 Optical Society of America

OCIS Codes
(170.1420) Medical optics and biotechnology : Biology
(170.3880) Medical optics and biotechnology : Medical and biological imaging
(290.7050) Scattering : Turbid media

ToC Category:
Medical Optics and Biotechnology

Original Manuscript: December 22, 2009
Revised Manuscript: February 18, 2010
Manuscript Accepted: February 25, 2010
Published: April 20, 2010

Virtual Issues
Vol. 5, Iss. 9 Virtual Journal for Biomedical Optics

Vaibhav Gaind, Sumith Kularatne, Philip S. Low, and Kevin J. Webb, "Deep-tissue imaging of intramolecular fluorescence resonance energy-transfer parameters," Opt. Lett. 35, 1314-1316 (2010)

Sort:  Author  |  Year  |  Journal  |  Reset  


  1. T. Förster, Ann. Phys. 2, 55 (1948). [CrossRef]
  2. K. Truong and M. Ikura, Curr. Opin. Struct. Biol. 11, 573 (2001). [CrossRef]
  3. J. Mills, J. Stone, D. Rubin, D. Melon, D. Okonkwo, and A. P. G. Helm, J. Biomed. Opt. 8, 347 (2003). [CrossRef] [PubMed]
  4. D. Stockholm, M. Bartoli, G. Sillon, N. Bourg, J. Davoust, and I. Richard, J. Mol. Biol. 346, 215 (2005). [CrossRef] [PubMed]
  5. V. Gaind, K. J. Webb, S. Kularatne, and C. A. Bouman, J. Opt. Soc. Am. A 26, 1805 (2009). [CrossRef]
  6. J. McGinty, V. Y. Soloviev, K. B. Tahir, R. Laine, D. W. Stuckey, J. V. Hajnal, A. Sardini, P. M. W. French, and S. R. Arridge, Opt. Lett. 34, 2772 (2009). [CrossRef] [PubMed]
  7. J. Yang, H. Chen, I. Vlahov, J. X. Cheng, and P. S. Low, Proc. Natl. Acad. Sci. USA 103, 13872 (2006). [CrossRef] [PubMed]
  8. P. S. Low, W. A. Henne, and D. D. Doorneweerd, Acc. Chem. Res. 41, 120 (2008). [CrossRef]
  9. E. Haas, ChemPhysChem 6, 858 (2005). [CrossRef] [PubMed]
  10. G. Hale and M. Querry, Appl. Opt. 12, 555 (1973). [CrossRef] [PubMed]
  11. A. B. Milstein, S. Oh, J. S. Reynolds, K. J. Webb, C. A. Bouman, and R. P. Millane, Opt. Lett. 27, 95 (2002). [CrossRef]

Cited By

Alert me when this paper is cited

OSA is able to provide readers links to articles that cite this paper by participating in CrossRef's Cited-By Linking service. CrossRef includes content from more than 3000 publishers and societies. In addition to listing OSA journal articles that cite this paper, citing articles from other participating publishers will also be listed.


Fig. 1 Fig. 2 Fig. 3
Fig. 4

« Previous Article  |  Next Article »

OSA is a member of CrossRef.

CrossCheck Deposited