A surface plasmon biosensing technique based on real-time measurement of the spectro-angular reflectance spectrum of a gold surface is presented. A significant improvement in refractive index resolution and drift compensation has been achieved for the spectro-angular technique to demonstrate a biosensing platform that is, in addition, applicable to plasmonic bandgap measurements. Instrumental improvements are detailed and constants for the model bovine serum albumin (BSA):oxacillin bioassay are presented.
© 2011 Optical Society of America
Instrumentation, Measurement, and Metrology
Original Manuscript: September 28, 2010
Manuscript Accepted: November 13, 2010
Published: December 23, 2010
Vol. 6, Iss. 2 Virtual Journal for Biomedical Optics
Colin J. Alleyne, Philip J. R. Roche, Sandrine Filion-Côté, and Andrew G. Kirk, "Analysis of surface plasmon spectro-angular reflectance spectrum: real-time measurement, resolution limits, and applications to biosensing," Opt. Lett. 36, 46-48 (2011)