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Optics Letters

Optics Letters


  • Vol. 36, Iss. 1 — Jan. 1, 2011
  • pp: 55–57

Quantitative x-ray phase-contrast imaging using a single grating of comparable pitch to sample feature size

Kaye S. Morgan, David M. Paganin, and Karen K. W. Siu  »View Author Affiliations

Optics Letters, Vol. 36, Issue 1, pp. 55-57 (2011)

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The ability to quantitatively retrieve transverse phase maps during imaging by using coherent x rays often requires a precise grating or analyzer-crystal-based setup. Imaging of live animals presents further challenges when these methods require multiple exposures for image reconstruction. We present a simple method of single-exposure, single-grating quantitative phase contrast for a regime in which the grating period is much greater than the effective pixel size. A grating is used to create a high-visibility reference pattern incident on the sample, which is distorted according to the complex refractive index and thickness of the sample. The resolution, along a line parallel to the grating, is not restricted by the grating spacing, and the detector resolution becomes the primary determinant of the spatial resolution. We present a method of analysis that maps the displacement of interrogation windows in order to retrieve a quantitative phase map. Application of this analysis to the imaging of known phantoms shows excellent correspondence.

© 2011 Optical Society of America

OCIS Codes
(100.5070) Image processing : Phase retrieval
(170.3880) Medical optics and biotechnology : Medical and biological imaging
(340.6720) X-ray optics : Synchrotron radiation
(340.7440) X-ray optics : X-ray imaging
(350.2770) Other areas of optics : Gratings
(110.3010) Imaging systems : Image reconstruction techniques

ToC Category:
Image Processing

Original Manuscript: September 1, 2010
Revised Manuscript: October 26, 2010
Manuscript Accepted: November 13, 2010
Published: December 27, 2010

Virtual Issues
Vol. 6, Iss. 2 Virtual Journal for Biomedical Optics

Kaye S. Morgan, David M. Paganin, and Karen K. W. Siu, "Quantitative x-ray phase-contrast imaging using a single grating of comparable pitch to sample feature size," Opt. Lett. 36, 55-57 (2011)

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