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Optics Letters


  • Vol. 36, Iss. 10 — May. 15, 2011
  • pp: 1866–1868

Circular polarization intrinsic optical signal recording of stimulus-evoked neural activity

Rong-Wen Lu, Qiu-Xiang Zhang, and Xin-Cheng Yao  »View Author Affiliations

Optics Letters, Vol. 36, Issue 10, pp. 1866-1868 (2011)

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Linear polarization intrinsic optical signal (LP-IOS) measurement can provide sensitive detection of neural activities in stimulus-activated neural tissues. However, the LP-IOS magnitude and signal-to-noise ratio (SNR) are highly correlated with the nerve orientation relative to the polarization plane of the incident light. Because of the complexity of orientation dependency, LP-IOS optimization and outcome interpretation are time consuming and complicated. In this study, we demonstrate the feasibility of circular polarization intrinsic optical signal (CP-IOS) measurement. Our theoretical modeling and experimental investigation indicate that CP-IOS magnitude and SNR are independent from the nerve orientation. Therefore, CP-IOS promises a practical method for polarization IOS imaging of complex neural systems.

© 2011 Optical Society of America

OCIS Codes
(170.1420) Medical optics and biotechnology : Biology
(170.3660) Medical optics and biotechnology : Light propagation in tissues
(170.3890) Medical optics and biotechnology : Medical optics instrumentation

ToC Category:
Medical Optics and Biotechnology

Original Manuscript: February 22, 2011
Revised Manuscript: April 18, 2011
Manuscript Accepted: April 19, 2011
Published: May 11, 2011

Virtual Issues
Vol. 6, Iss. 6 Virtual Journal for Biomedical Optics

Rong-Wen Lu, Qiu-Xiang Zhang, and Xin-Cheng Yao, "Circular polarization intrinsic optical signal recording of stimulus-evoked neural activity," Opt. Lett. 36, 1866-1868 (2011)

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