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Optics Letters

Optics Letters

| RAPID, SHORT PUBLICATIONS ON THE LATEST IN OPTICAL DISCOVERIES

  • Vol. 36, Iss. 10 — May. 15, 2011
  • pp: 1911–1913

Dark-field scanning in situ spectroscopy platform for broadband imaging of resected tissue

Venkataramanan Krishnaswamy, Ashley M. Laughney, Keith D. Paulsen, and Brian W. Pogue  »View Author Affiliations


Optics Letters, Vol. 36, Issue 10, pp. 1911-1913 (2011)
http://dx.doi.org/10.1364/OL.36.001911


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Abstract

A dark-field geometry spectral imaging system is presented to raster scan thick tissue samples in situ in 1.5 cm square sections, recovering full spectra from each 100 μm diameter pixel. This spot size provides adequate resolution for wide field scanning, while also facilitating scatter imaging without requiring sophisticated light–tissue transport modeling. The system is demonstrated showing accurate estimation of localized scatter parameters and the potential to recover absorption-based contrast from broadband reflectance data measured from 480 nm up to 750 nm in tissue phantoms. Results obtained from xenograft pancreas tumors show the ability to quantitatively image changes in localized scatter response in this fast-imaging geometry. The polychromatic raster scan design allows the rapid scanning necessary for use in surgical/clinical applications where timely decisions are required about tissue pathology.

© 2011 Optical Society of America

OCIS Codes
(170.0110) Medical optics and biotechnology : Imaging systems
(170.6510) Medical optics and biotechnology : Spectroscopy, tissue diagnostics

ToC Category:
Medical Optics and Biotechnology

History
Original Manuscript: November 29, 2010
Revised Manuscript: April 6, 2011
Manuscript Accepted: April 8, 2011
Published: May 13, 2011

Virtual Issues
Vol. 6, Iss. 6 Virtual Journal for Biomedical Optics

Citation
Venkataramanan Krishnaswamy, Ashley M. Laughney, Keith D. Paulsen, and Brian W. Pogue, "Dark-field scanning in situ spectroscopy platform for broadband imaging of resected tissue," Opt. Lett. 36, 1911-1913 (2011)
http://www.opticsinfobase.org/ol/abstract.cfm?URI=ol-36-10-1911

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