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Optics Letters

Optics Letters


  • Vol. 36, Iss. 11 — Jun. 1, 2011
  • pp: 2116–2118

Differential laser-induced perturbation spectroscopy using a deep-ultraviolet excimer laser

Sarah E. Smith, Leia M. Shanyfelt, Katherine D. Buchanan, and David W. Hahn  »View Author Affiliations

Optics Letters, Vol. 36, Issue 11, pp. 2116-2118 (2011)

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Here we demonstrate a unique optical sensing scheme based on deep-UV photochemical perturbation in combination with difference spectroscopy. Applying a sequence of optical probing, UV-laser-induced perturbation, and repeat optical probing coupled with difference spectroscopy provides a new spectral signature. We show a selective (sevenfold difference) optical response using a fluorescence probe for binary mixtures of organic dyes, and generate complementary spectral information derived from Raman scattering of the dipeptide glycine-glycine. We further extend the methodology to fluorescence-based imaging of an organic matrix.

© 2011 Optical Society of America

OCIS Codes
(170.4580) Medical optics and biotechnology : Optical diagnostics for medicine
(300.2530) Spectroscopy : Fluorescence, laser-induced
(300.6330) Spectroscopy : Spectroscopy, inelastic scattering including Raman
(170.2655) Medical optics and biotechnology : Functional monitoring and imaging

ToC Category:
Medical Optics and Biotechnology

Original Manuscript: February 15, 2011
Revised Manuscript: April 5, 2011
Manuscript Accepted: May 9, 2011
Published: May 31, 2011

Virtual Issues
Vol. 6, Iss. 7 Virtual Journal for Biomedical Optics

Sarah E. Smith, Leia M. Shanyfelt, Katherine D. Buchanan, and David W. Hahn, "Differential laser-induced perturbation spectroscopy using a deep-ultraviolet excimer laser," Opt. Lett. 36, 2116-2118 (2011)

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  1. H. Gorner, J. Photochem. Photobiol. B 26, 117 (1994). [CrossRef] [PubMed]
  2. B. T. Fisher and D. W. Hahn, Appl. Opt. 43, 5443 (2004). [CrossRef] [PubMed]
  3. P. Lagant, G. Vergoten, M. H. Loucheux-Lefebvre, and G. Fleury, Biopolymers 22, 1267 (1983). [CrossRef] [PubMed]
  4. S. E. Smith, K. D. Buchanan, and D. W. Hahn, Proc. SPIE 7674, 767409 (2010). [CrossRef]
  5. K. Bagley, G. Dollinger, L. Eisenstein, A. K. Singh, and L. Zimanyi, Proc. Natl. Acad. Sci. USA 79, 4972 (1982). [CrossRef] [PubMed]
  6. E. A. J. Reits and J. J. Neefjes, Nat. Cell Biol. 3, E145 (2001). [CrossRef] [PubMed]

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