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Optics Letters

Optics Letters


  • Vol. 36, Iss. 16 — Aug. 15, 2011
  • pp: 3169–3171

Supercontinuum light source enables in vivo optical microangiography of capillary vessels within tissue beds

Zhongwei Zhi, Jia Qin, Lin An, and Ruikang K. Wang  »View Author Affiliations

Optics Letters, Vol. 36, Issue 16, pp. 3169-3171 (2011)

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This Letter reports on the use of a supercontinuum light source to achieve ultrahigh resolution and ultrahigh sensitive optical microangiography (OMAG) imaging of microcirculations within tissue beds in vivo. After passing through a specially designed optical filter with a passband of 120 nm centered on 800 nm , the light source is coupled into an optic-fiber-based OMAG system that provides a measured axial resolution of 3 μm over a ranging distance of 2 mm . Within this ranging distance, the system gives an averaged signal-to-noise ratio of 87 dB and a sensitivity roll-off of 7 dB at an A-scan rate of 70 kHz . We demonstrate the capability of the system to visualize a detailed microvascular perfusion map, including the single red blood cells within the capillaries, by imaging a mouse ear flap in vivo.

© 2011 Optical Society of America

OCIS Codes
(170.3880) Medical optics and biotechnology : Medical and biological imaging
(170.4500) Medical optics and biotechnology : Optical coherence tomography

ToC Category:
Medical Optics and Biotechnology

Original Manuscript: June 15, 2011
Revised Manuscript: July 17, 2011
Manuscript Accepted: July 18, 2011
Published: August 11, 2011

Virtual Issues
Vol. 6, Iss. 9 Virtual Journal for Biomedical Optics

Zhongwei Zhi, Jia Qin, Lin An, and Ruikang K. Wang, "Supercontinuum light source enables in vivooptical microangiography of capillary vessels within tissue beds," Opt. Lett. 36, 3169-3171 (2011)

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