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Optics Letters

Optics Letters


  • Vol. 36, Iss. 17 — Sep. 1, 2011
  • pp: 3320–3322

Vernier-cascade label-free biosensor with integrated arrayed waveguide grating for wavelength interrogation with low-cost broadband source

Tom Claes, Wim Bogaerts, and Peter Bienstman  »View Author Affiliations

Optics Letters, Vol. 36, Issue 17, pp. 3320-3322 (2011)

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Recently, cheap silicon-on-insulator label-free biosensors have been demonstrated that allow fast and accurate quantitative detection of biologically relevant molecules for applications in medical diagnostics and drug development. However, whereas the sensor chip can be made cheaply, an expensive tunable laser is typically required to accurately monitor spectral shifts in the sensor’s transmission spectrum (wavelength interrogation). To address this issue, we integrated a very sensitive Vernier-cascade sensor with an arrayed waveguide grating spectral filter that divides the sensor’s transmission spectrum in multiple wavelength channels and transmits them to spatially separated output ports, allowing wavelength interrogation with a much cheaper broadband light source. Experiments show that this sensor can monitor refractive index changes of watery solutions in real time with a detection limit ( 1.6 · 10 5 RIU ) competitive with more expensive interrogation schemes, indicating its applicability in low-cost label-free biosensing. The relaxation on the complexity of the source, moreover, offers the prospect to integrate the source and detectors to further reduce the device cost and to increase its portability.

© 2011 Optical Society of America

OCIS Codes
(130.6010) Integrated optics : Sensors
(280.1415) Remote sensing and sensors : Biological sensing and sensors
(130.7408) Integrated optics : Wavelength filtering devices

ToC Category:
Integrated Optics

Original Manuscript: June 10, 2011
Revised Manuscript: July 25, 2011
Manuscript Accepted: July 27, 2011
Published: August 19, 2011

Virtual Issues
Vol. 6, Iss. 10 Virtual Journal for Biomedical Optics

Tom Claes, Wim Bogaerts, and Peter Bienstman, "Vernier-cascade label-free biosensor with integrated arrayed waveguide grating for wavelength interrogation with low-cost broadband source," Opt. Lett. 36, 3320-3322 (2011)

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  1. A. J. Qavi, A. L. Washburn, J.-Y. Byeon, and R. C. Bailey, Anal. Bioanal. Chem. 394, 121 (2009). [CrossRef] [PubMed]
  2. K. De Vos, J. Girones, T. Claes, Y. De Koninck, S. Popelka, E. Schacht, R. Baets, and P. Bienstman, IEEE Photon. J. 1, 225 (2009). [CrossRef]
  3. M. Iqbal, M. A. Gleeson, B. Spaugh, F. Tybor, W. G. Gunn, M. Hochberg, T. Baehr-Jones, R. C. Bailey, and L. C. Gunn, IEEE J. Sel. Top. Quantum Electron. 16, 654 (2010). [CrossRef]
  4. D. X. Xu, M. Vachon, A. Densmore, R. Ma, A. Delage, S. Janz, J. Lapointe, Y. Li, G. Lopinski, D. Zhang, Q. Y. Liu, P. Cheben, and J. H. Schmid, Opt. Lett. 35, 2771 (2010). [CrossRef] [PubMed]
  5. B. Sepulveda, J. Sanchez del Rio, M. Moreno, F. J. Blanco, K. Mayora, C. Dominguez, and L. M. Lechuga, J. Opt. A 8, S561 (2006). [CrossRef]
  6. P. S. Petrou, M. Kitsara, E. Makarona, I. Raptis, S. E. Kakabakos, R. Stoffer, and G. Jobst, in Conference of Proceedings of IEEE English Medical Biological Society (2010), p. 298.
  7. L. Jin, M. Li, and J.-J. He, Opt. Lett. 36, 1128 (2011). [CrossRef] [PubMed]
  8. Z. Xia, B. Momeni, M. Askari, M. Chamanzar, S. Yegnanarayanan, A. A. Eftekhar, and A. Adibi, in IEEE Photonics Annual Meeting (2010), pp. 329–330. [CrossRef]
  9. T. Claes, W. Bogaerts, and P. Bienstman, Opt. Express 18, 22747 (2010). [CrossRef] [PubMed]
  10. L. Jin, M. Li, and J.-J. He, Opt. Commun. 284, 156 (2011). [CrossRef]
  11. W. Bogaerts, S. K. Selvaraja, P. Dumon, J. Brouckaert, K. De Vos, D. Van Thourhout, and R. Baets, IEEE J. Sel. Top. Quantum Electron. 16, 33 (2010). [CrossRef]
  12. H. Su and X. G. Huang, Sens. Actuators. B 126, 579 (2007). [CrossRef]

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