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Optics Letters


  • Vol. 36, Iss. 18 — Sep. 15, 2011
  • pp: 3599–3601

Nonionizing photoacoustic cystography in vivo

Chulhong Kim, Mansik Jeon, and Lihong V. Wang  »View Author Affiliations

Optics Letters, Vol. 36, Issue 18, pp. 3599-3601 (2011)

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We demonstrate the feasibility of a novel and nonionizing process for bladder imaging in vivo, called photoacoustic cystography (PAC). Using a photoacoustic imaging system, we have successfully imaged a rat bladder filled with clinically used Methylene Blue (MB) dye. An image contrast of ~ 8 was achieved. Further, spectroscopic PAC confirmed the accumulation of MB in the bladder. Using a laser pulse energy of less than 1 mJ / cm 2 ( 1 / 20 of the ANSI safety limit), a deeply ( 1.2 cm ) positioned bladder in biological tissues was clearly visible in the PA image. Our results suggest that PAC can potentially provide a nonionizing, relatively cheap, and portable tool for bladder mapping. Among our clinical interests, nonionizing PAC with an injection of MB can potentially monitor vesicoureteral reflux in children.

© 2011 Optical Society of America

OCIS Codes
(110.0110) Imaging systems : Imaging systems
(170.0170) Medical optics and biotechnology : Medical optics and biotechnology
(170.5120) Medical optics and biotechnology : Photoacoustic imaging

ToC Category:
Medical Optics and Biotechnology

Original Manuscript: June 24, 2011
Revised Manuscript: August 7, 2011
Manuscript Accepted: August 16, 2011
Published: September 12, 2011

Virtual Issues
Vol. 6, Iss. 10 Virtual Journal for Biomedical Optics

Chulhong Kim, Mansik Jeon, and Lihong V. Wang, "Nonionizing photoacoustic cystography in vivo," Opt. Lett. 36, 3599-3601 (2011)

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