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In vivo flow speed measurement of capillaries by photoacoustic correlation spectroscopy |
Optics Letters, Vol. 36, Issue 20, pp. 4017-4019 (2011)
http://dx.doi.org/10.1364/OL.36.004017
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Abstract
We recently proposed photoacoustic correlation spectroscopy (PACS) and demonstrated a proof-of-concept experiment. Here we use the technique for in vivo flow speed measurement in capillaries in a chick embryo model. The photoacoustic microscopy system is used to render high spatial resolution and high sensitivity, enabling sufficient signals from single red blood cells. The probe beam size is calibrated by a blood-mimicking phantom. The results indicate the feasibility of using PACS to study flow speeds in capillaries.
© 2011 Optical Society of America
OCIS Codes
(120.7250) Instrumentation, measurement, and metrology : Velocimetry
(170.5120) Medical optics and biotechnology : Photoacoustic imaging
ToC Category:
Medical Optics and Biotechnology
History
Original Manuscript: July 21, 2011
Revised Manuscript: September 12, 2011
Manuscript Accepted: September 13, 2011
Published: October 6, 2011
Virtual Issues
Vol. 6, Iss. 11 Virtual Journal for Biomedical Optics
Citation
Sung-Liang Chen, Zhixing Xie, Paul L. Carson, Xueding Wang, and L. Jay Guo, "In vivo flow speed measurement of capillaries by photoacoustic correlation spectroscopy," Opt. Lett. 36, 4017-4019 (2011)
http://www.opticsinfobase.org/ol/abstract.cfm?URI=ol-36-20-4017
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