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Optics Letters

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  • Vol. 36, Iss. 20 — Oct. 15, 2011
  • pp: 4107–4109

Label-free in vivo fiber-based optical-resolution photoacoustic microscopy

P. Hajireza, W. Shi, and R. J. Zemp  »View Author Affiliations


Optics Letters, Vol. 36, Issue 20, pp. 4107-4109 (2011)
http://dx.doi.org/10.1364/OL.36.004107


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Abstract

In this Letter, the capability of label-free fiber-based optical-resolution photoacoustic microscopy is demonstrated. This real-time imaging system takes advantage of image-guide fibers and a unique fiber laser. The 800 μm image-guide consists of 30,000 individual single-mode fibers in a bundle and the diode-pumped, pulsed Ytterbium fiber laser is utilized to perform up to 600 kHz repetition rate. Phantom studies indicate 7 μm resolution. The proposed setup keeps many of the powerful properties of previous tabletop OR-PAM systems, but also offers a submillimeter probe footprint and high flexibility due to the nature of the image-guide. This system could have significant clinical impact for endoscopic applications where the thin fiber can be inserted into the body.

© 2011 Optical Society of America

OCIS Codes
(110.0180) Imaging systems : Microscopy
(110.2350) Imaging systems : Fiber optics imaging
(110.5120) Imaging systems : Photoacoustic imaging

ToC Category:
Imaging Systems

History
Original Manuscript: June 13, 2011
Revised Manuscript: July 27, 2011
Manuscript Accepted: September 6, 2011
Published: October 14, 2011

Virtual Issues
Vol. 6, Iss. 11 Virtual Journal for Biomedical Optics

Citation
P. Hajireza, W. Shi, and R. J. Zemp, "Label-free in vivo fiber-based optical-resolution photoacoustic microscopy," Opt. Lett. 36, 4107-4109 (2011)
http://www.opticsinfobase.org/ol/abstract.cfm?URI=ol-36-20-4107


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References

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