OSA's Digital Library

Optics Letters

Optics Letters


  • Editor: Alan E. Willner
  • Vol. 36, Iss. 22 — Nov. 15, 2011
  • pp: 4329–4331

Revisiting the normalized Born approximation: effects of scattering

Thomas Pyka, Ralf Schulz, Angelique Ale, and Vasilis Ntziachristos  »View Author Affiliations

Optics Letters, Vol. 36, Issue 22, pp. 4329-4331 (2011)

View Full Text Article

Enhanced HTML    Acrobat PDF (342 KB)

Browse Journals / Lookup Meetings

Browse by Journal and Year


Lookup Conference Papers

Close Browse Journals / Lookup Meetings

Article Tools



The normalized Born approximation has been suggested as a ratiometric method in fluorescence molecular tomography (FMT) applications, to account for heterogeneity variations. The method enabled practical inversions, as it offered fluorescence reconstruction accuracy over a wide range of absorption heterogeneity, while also accounting for unknown experimental factors, such as the various system gains and losses. Yet it was noted that scattering variations affect the robustness and accuracy. Herein we decompose the effects of absorption and scattering and capitalize on the recent development of hybrid FMT/x-ray computed tomography imaging methods to proposed amendments to the method, which improve the overall accuracy of the approach.

© 2011 Optical Society of America

OCIS Codes
(170.0170) Medical optics and biotechnology : Medical optics and biotechnology
(170.5120) Medical optics and biotechnology : Photoacoustic imaging
(170.6960) Medical optics and biotechnology : Tomography

ToC Category:
Medical Optics and Biotechnology

Original Manuscript: August 1, 2011
Revised Manuscript: September 23, 2011
Manuscript Accepted: October 7, 2011
Published: November 9, 2011

Virtual Issues
Vol. 7, Iss. 1 Virtual Journal for Biomedical Optics

Thomas Pyka, Ralf Schulz, Angelique Ale, and Vasilis Ntziachristos, "Revisiting the normalized Born approximation: effects of scattering," Opt. Lett. 36, 4329-4331 (2011)

Sort:  Author  |  Year  |  Journal  |  Reset  


  1. S. Arridge, Inverse Probl. 15, R41 (1999). [CrossRef]
  2. S. Davis, H. Dehghani, J. Wang, S. Jiang, B. Pogue, and K. Paulsen, Opt. Express 15, 4066 (2007). [CrossRef] [PubMed]
  3. V. Ntziachristos, C.-H. Tung, C. Bremer, and R. Weissleder, Nat. Med. 8, 757 (2002). [CrossRef] [PubMed]
  4. V. Ntziachristos and R. Weissleder, Opt. Lett. 26, 893(2001). [CrossRef]
  5. A. Soubret, J. Ripoll, and V. Ntziachristos, IEEE Trans. Med. Imaging 24, 1377 (2005). [CrossRef] [PubMed]
  6. W. Bangerth, R. Hartmann, and G. Kanschat, ACM Trans. Math. Softw. 33, 24 (2007). [CrossRef]
  7. R. Schulz, A. Ale, A. Sarantopoulos, M. Freyer, E. Soehngen, M. Zientkowska, and V. Ntziachristos, IEEE Trans. Med. Imaging 29, 465 (2010). [CrossRef]
  8. Z. Wang and A. C. Bovik, IEEE Signal Proc. Lett. 9, 81(2002). [CrossRef]
  9. Y. Lin, W. C. Barber, J. S. Iwanczyk, W. Roeck, O. Nalcioglu, and G. Gulsen, Opt. Express 18, 7835 (2010). [CrossRef] [PubMed]
  10. D. Hyde, R. Schulz, D. Brooks, E. Miller, and V. Ntziachristos, J. Opt. Soc. Am. A 26, 919 (2009). [CrossRef]

Cited By

Alert me when this paper is cited

OSA is able to provide readers links to articles that cite this paper by participating in CrossRef's Cited-By Linking service. CrossRef includes content from more than 3000 publishers and societies. In addition to listing OSA journal articles that cite this paper, citing articles from other participating publishers will also be listed.


Fig. 1 Fig. 2 Fig. 3

« Previous Article  |  Next Article »

OSA is a member of CrossRef.

CrossCheck Deposited