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Optics Letters

Optics Letters

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  • Editor: Alan E. Willner
  • Vol. 36, Iss. 22 — Nov. 15, 2011
  • pp: 4329–4331

Revisiting the normalized Born approximation: effects of scattering

Thomas Pyka, Ralf Schulz, Angelique Ale, and Vasilis Ntziachristos  »View Author Affiliations


Optics Letters, Vol. 36, Issue 22, pp. 4329-4331 (2011)
http://dx.doi.org/10.1364/OL.36.004329


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Abstract

The normalized Born approximation has been suggested as a ratiometric method in fluorescence molecular tomography (FMT) applications, to account for heterogeneity variations. The method enabled practical inversions, as it offered fluorescence reconstruction accuracy over a wide range of absorption heterogeneity, while also accounting for unknown experimental factors, such as the various system gains and losses. Yet it was noted that scattering variations affect the robustness and accuracy. Herein we decompose the effects of absorption and scattering and capitalize on the recent development of hybrid FMT/x-ray computed tomography imaging methods to proposed amendments to the method, which improve the overall accuracy of the approach.

© 2011 Optical Society of America

OCIS Codes
(170.0170) Medical optics and biotechnology : Medical optics and biotechnology
(170.5120) Medical optics and biotechnology : Photoacoustic imaging
(170.6960) Medical optics and biotechnology : Tomography

ToC Category:
Medical Optics and Biotechnology

History
Original Manuscript: August 1, 2011
Revised Manuscript: September 23, 2011
Manuscript Accepted: October 7, 2011
Published: November 9, 2011

Virtual Issues
Vol. 7, Iss. 1 Virtual Journal for Biomedical Optics

Citation
Thomas Pyka, Ralf Schulz, Angelique Ale, and Vasilis Ntziachristos, "Revisiting the normalized Born approximation: effects of scattering," Opt. Lett. 36, 4329-4331 (2011)
http://www.opticsinfobase.org/ol/abstract.cfm?URI=ol-36-22-4329

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