We demonstrate intravascular photoacoustic imaging of human coronary atherosclerotic plaque. The data was obtained from two fresh human coronary arteries ex vivo, showing different stages of disease. A $1.25\mathrm{mm}$ diameter intravascular imaging catheter was built, comprising an angle-polished optical fiber adjacent to a $30\mathrm{MHz}$ ultrasound transducer. Specific photoacoustic imaging of lipid content, a key factor in vulnerable plaques that may lead to myocardial infarction, is achieved by spectroscopic imaging at different wavelengths between 1180 and $1230\mathrm{nm}$ . Simultaneous imaging with intravascular ultrasound was performed.

© 2011 Optical Society of America

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