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Optics Letters

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  • Vol. 36, Iss. 7 — Apr. 1, 2011
  • pp: 1134–1136

Second-generation optical-resolution photoacoustic microscopy with improved sensitivity and speed

Song Hu, Konstantin Maslov, and Lihong V. Wang  »View Author Affiliations


Optics Letters, Vol. 36, Issue 7, pp. 1134-1136 (2011)
http://dx.doi.org/10.1364/OL.36.001134


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Abstract

We developed second-generation (G2) optical-resolution photoacoustic microscopy (OR-PAM). Incorporation of a novel acoustic detection scheme improved upon the sensitivity of our first-generation (G1) system by 18.4 dB , deepening the in vivo tissue penetration to 1.2 mm at 570 nm . Moreover, translating the imaging head instead of the living object accelerated the scanning speed by a factor of 5, widening the field of view within the same acquisition time. Mouse ears, as well as mouse brains with intact craniums, were imaged in vivo in both total concentration and oxygen saturation of hemoglobin.

© 2011 Optical Society of America

OCIS Codes
(170.3880) Medical optics and biotechnology : Medical and biological imaging
(170.5120) Medical optics and biotechnology : Photoacoustic imaging
(180.5810) Microscopy : Scanning microscopy

ToC Category:
Medical Optics and Biotechnology

History
Original Manuscript: December 21, 2010
Manuscript Accepted: February 3, 2011
Published: March 23, 2011

Virtual Issues
Vol. 6, Iss. 5 Virtual Journal for Biomedical Optics

Citation
Song Hu, Konstantin Maslov, and Lihong V. Wang, "Second-generation optical-resolution photoacoustic microscopy with improved sensitivity and speed," Opt. Lett. 36, 1134-1136 (2011)
http://www.opticsinfobase.org/ol/abstract.cfm?URI=ol-36-7-1134

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