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Optics Letters

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  • Vol. 36, Iss. 7 — Apr. 1, 2011
  • pp: 1137–1139

Real-time four-dimensional optical-resolution photoacoustic microscopy with Au nanoparticle-assisted subdiffraction-limit resolution

Bin Rao, Konstantin Maslov, Amos Danielli, Ruimin Chen, K. Kirk Shung, Qifa Zhou, and Lihong V. Wang  »View Author Affiliations


Optics Letters, Vol. 36, Issue 7, pp. 1137-1139 (2011)
http://dx.doi.org/10.1364/OL.36.001137


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Abstract

Photoacoustic microscopy (PAM) offers label-free, optical absorption contrast. A high-speed, high-resolution PAM system in an inverted microscope configuration with a laser pulse repetition rate of 100 , 000 Hz and a stationary ultrasonic transducer was built. Four-dimensional in vivo imaging of microcirculation in mouse skin was achieved at 18 three-dimensional volumes per second with repeated two-dimensional (2D) raster scans of 100 by 50 points. The corresponding 2D B-scan (50 A-lines) frame rate was 1800 Hz , and the one-dimensional A-scan rate was 90 , 000 Hz . The lateral resolution is 0.23 ± 0.03 μm for Au nanowire imaging, which is 2.0 times below the diffraction limit.

© 2011 Optical Society of America

OCIS Codes
(110.0180) Imaging systems : Microscopy
(110.5120) Imaging systems : Photoacoustic imaging
(170.3880) Medical optics and biotechnology : Medical and biological imaging
(170.5120) Medical optics and biotechnology : Photoacoustic imaging
(180.5810) Microscopy : Scanning microscopy

ToC Category:
Medical Optics and Biotechnology

History
Original Manuscript: January 19, 2011
Revised Manuscript: February 23, 2011
Manuscript Accepted: February 25, 2011
Published: March 23, 2011

Virtual Issues
Vol. 6, Iss. 5 Virtual Journal for Biomedical Optics

Citation
Bin Rao, Konstantin Maslov, Amos Danielli, Ruimin Chen, K. Kirk Shung, Qifa Zhou, and Lihong V. Wang, "Real-time four-dimensional optical-resolution photoacoustic microscopy with Au nanoparticle-assisted subdiffraction-limit resolution," Opt. Lett. 36, 1137-1139 (2011)
http://www.opticsinfobase.org/ol/abstract.cfm?URI=ol-36-7-1137


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References

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