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Optics Letters

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  • Vol. 36, Iss. 7 — Apr. 1, 2011
  • pp: 1236–1238

Multifocal optical-resolution photoacoustic microscopy in vivo

Liang Song, Konstantin Maslov, and Lihong V. Wang  »View Author Affiliations


Optics Letters, Vol. 36, Issue 7, pp. 1236-1238 (2011)
http://dx.doi.org/10.1364/OL.36.001236


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Abstract

Although ultrasound arrays have been exploited in photoacoustic imaging to improve imaging speed, ultrasound-array-based optical-resolution photoacoustic microscopy (OR-PAM) has never been achieved previously to our knowledge. Here we present our development of multifocal OR-PAM using a microlens array for optical illumination and an ultrasound array for photoacoustic detection. Our system is capable of imaging hemoglobin concentration and oxygenation in individual microvessels in vivo at high speed. Compared with a single focus, multiple foci reduce the scanning load and increase the imaging speed significantly. The current multifocal system can acquire 1000 × 500 × 200 voxels at 10 μm lateral resolution within 4 min .

© 2011 Optical Society of America

OCIS Codes
(170.0110) Medical optics and biotechnology : Imaging systems
(170.0180) Medical optics and biotechnology : Microscopy
(170.3880) Medical optics and biotechnology : Medical and biological imaging
(170.5120) Medical optics and biotechnology : Photoacoustic imaging

ToC Category:
Medical Optics and Biotechnology

History
Original Manuscript: November 23, 2010
Revised Manuscript: February 11, 2011
Manuscript Accepted: February 27, 2011
Published: March 29, 2011

Virtual Issues
Vol. 6, Iss. 5 Virtual Journal for Biomedical Optics

Citation
Liang Song, Konstantin Maslov, and Lihong V. Wang, "Multifocal optical-resolution photoacoustic microscopy in vivo," Opt. Lett. 36, 1236-1238 (2011)
http://www.opticsinfobase.org/ol/abstract.cfm?URI=ol-36-7-1236

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