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Multifocal optical-resolution photoacoustic microscopy in vivo |
Optics Letters, Vol. 36, Issue 7, pp. 1236-1238 (2011)
http://dx.doi.org/10.1364/OL.36.001236
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Abstract
Although ultrasound arrays have been exploited in photoacoustic imaging to improve imaging speed, ultrasound-array-based optical-resolution photoacoustic microscopy (OR-PAM) has never been achieved previously to our knowledge. Here we present our development of multifocal OR-PAM using a microlens array for optical illumination and an ultrasound array for photoacoustic detection. Our system is capable of imaging hemoglobin concentration and oxygenation in individual microvessels in vivo at high speed. Compared with a single focus, multiple foci reduce the scanning load and increase the imaging speed significantly. The current multifocal system can acquire
© 2011 Optical Society of America
OCIS Codes
(170.0110) Medical optics and biotechnology : Imaging systems
(170.0180) Medical optics and biotechnology : Microscopy
(170.3880) Medical optics and biotechnology : Medical and biological imaging
(170.5120) Medical optics and biotechnology : Photoacoustic imaging
ToC Category:
Medical Optics and Biotechnology
History
Original Manuscript: November 23, 2010
Revised Manuscript: February 11, 2011
Manuscript Accepted: February 27, 2011
Published: March 29, 2011
Virtual Issues
Vol. 6, Iss. 5 Virtual Journal for Biomedical Optics
Citation
Liang Song, Konstantin Maslov, and Lihong V. Wang, "Multifocal optical-resolution photoacoustic microscopy in vivo," Opt. Lett. 36, 1236-1238 (2011)
http://www.opticsinfobase.org/ol/abstract.cfm?URI=ol-36-7-1236
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