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  • Vol. 36, Iss. 7 — Apr. 1, 2011
  • pp: 1299–1301

Compensation-free, all-fiber-optic, two-photon endomicroscopy at 1.55 μm

Kartikeya Murari, Yuying Zhang, Shenping Li, Yongping Chen, Ming-Jun Li, and Xingde Li  »View Author Affiliations


Optics Letters, Vol. 36, Issue 7, pp. 1299-1301 (2011)
http://dx.doi.org/10.1364/OL.36.001299


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Abstract

We present an all-fiber-optic scanning multiphoton endomicroscope with 1.55 μm excitation without the need for prechirping femtosecond pulses before the endomicroscope. The system consists of a 1.55 μm femtosecond fiber laser, a customized double-clad fiber for light delivery and fluorescence collection, and a piezoelectric scan head. We demonstrate two-photon imaging of cultured cells and mouse tissue, both labeled with indocyanine green. Free-space multiphoton imaging with near-IR emission has previously shown benefits in reduced background fluorescence and lower attenuation for the fluorescence emission. For fiber-optic multiphoton imaging there is the additional advantage of using the soliton effect at the telecommunication wavelengths ( 1.3 1.6 μm ) in fibers, permitting dispersion-compensation-free, small-footprint systems. We expect these advantages will help transition multiphoton endomicroscopy to the clinic.

© 2011 Optical Society of America

OCIS Codes
(170.2150) Medical optics and biotechnology : Endoscopic imaging
(190.0190) Nonlinear optics : Nonlinear optics

ToC Category:
Medical Optics and Biotechnology

History
Original Manuscript: January 11, 2011
Revised Manuscript: February 23, 2011
Manuscript Accepted: February 25, 2011
Published: April 1, 2011

Virtual Issues
Vol. 6, Iss. 5 Virtual Journal for Biomedical Optics

Citation
Kartikeya Murari, Yuying Zhang, Shenping Li, Yongping Chen, Ming-Jun Li, and Xingde Li, "Compensation-free, all-fiber-optic, two-photon endomicroscopy at 1.55 μm," Opt. Lett. 36, 1299-1301 (2011)
http://www.opticsinfobase.org/ol/abstract.cfm?URI=ol-36-7-1299


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