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Optics Letters

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  • Vol. 36, Iss. 8 — Apr. 15, 2011
  • pp: 1353–1355

Colocalization of gold nanoparticle-conjugated DNA hybridization for enhanced surface plasmon detection using nanograting antennas

Youngjin Oh, Wonju Lee, and Donghyun Kim  »View Author Affiliations


Optics Letters, Vol. 36, Issue 8, pp. 1353-1355 (2011)
http://dx.doi.org/10.1364/OL.36.001353


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Abstract

We have investigated enhanced surface plasmon resonance detection through colocalization of gold nanoparticle (GNP)-conjugated target molecules and near-fields established by nanograting-based antennas. The target colocalization was implemented by angled dielectric thin-film deposition on the nanograting structure. The concept was tested by detecting DNA hybridization and shows that the colocalization produces an additional 60%–80% increase of resonance shifts. The colocalization involves a much smaller number of target molecules, so that the measured enhancement per molecule by the colocalization of GNP-conjugated DNA oligomers was estimated to be by more than 2 orders of magnitude relative to that of thin-film-based conventional detection.

© 2011 Optical Society of America

OCIS Codes
(120.1880) Instrumentation, measurement, and metrology : Detection
(240.6680) Optics at surfaces : Surface plasmons
(310.6628) Thin films : Subwavelength structures, nanostructures

ToC Category:
Instrumentation, Measurement, and Metrology

History
Original Manuscript: November 9, 2010
Revised Manuscript: February 22, 2011
Manuscript Accepted: March 11, 2011
Published: April 7, 2011

Virtual Issues
Vol. 6, Iss. 5 Virtual Journal for Biomedical Optics

Citation
Youngjin Oh, Wonju Lee, and Donghyun Kim, "Colocalization of gold nanoparticle-conjugated DNA hybridization for enhanced surface plasmon detection using nanograting antennas," Opt. Lett. 36, 1353-1355 (2011)
http://www.opticsinfobase.org/ol/abstract.cfm?URI=ol-36-8-1353

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