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Optics Letters

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  • Vol. 37, Iss. 13 — Jul. 1, 2012
  • pp: 2559–2561

Multiple-gate time domain diffuse fluorescence tomography allows more sparse tissue sampling without compromising image quality

Robert W. Holt, Kenneth M. Tichauer, Hamid Dehghani, Brian W. Pogue, and Frederic Leblond  »View Author Affiliations


Optics Letters, Vol. 37, Issue 13, pp. 2559-2561 (2012)
http://dx.doi.org/10.1364/OL.37.002559


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Abstract

Diffuse fluorescence tomography systems that employ highly sensitive photo-multiplier tubes for single-photon detection are pushing the sensitivity limits of the field. However, each of these detectors only offers a single data projection to be collected, implying these imaging systems either require many detectors or long scan times to collect full data sets for image reconstruction. This study presents a method of utilizing the time-resolved collection capabilities of time-correlated single-photon counting techniques to increase spatial resolution and to reduce the number of data projections to produce reliable fluorescence reconstructions. Experimental tissue phantom results demonstrate that using data at 10 time gates in the fluorescence reconstructions for only 40 data projections provided superior image accuracy when compared to reconstructions on 320 continuous-wave data projections.

© 2012 Optical Society of America

OCIS Codes
(110.6960) Imaging systems : Tomography
(170.3660) Medical optics and biotechnology : Light propagation in tissues
(110.0113) Imaging systems : Imaging through turbid media
(110.3010) Imaging systems : Image reconstruction techniques

ToC Category:
Imaging Systems

History
Original Manuscript: February 7, 2012
Revised Manuscript: March 29, 2012
Manuscript Accepted: April 18, 2012
Published: June 21, 2012

Virtual Issues
Vol. 7, Iss. 9 Virtual Journal for Biomedical Optics

Citation
Robert W. Holt, Kenneth M. Tichauer, Hamid Dehghani, Brian W. Pogue, and Frederic Leblond, "Multiple-gate time domain diffuse fluorescence tomography allows more sparse tissue sampling without compromising image quality," Opt. Lett. 37, 2559-2561 (2012)
http://www.opticsinfobase.org/ol/abstract.cfm?URI=ol-37-13-2559


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