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Optics Letters

Optics Letters


  • Editor: Alan E. Willner
  • Vol. 37, Iss. 14 — Jul. 15, 2012
  • pp: 2952–2954

Coherence-multiplexed, label-free biomolecular interaction analysis

Sajal Chirvi, Zexuan Qiang, and Digant P. Davé  »View Author Affiliations

Optics Letters, Vol. 37, Issue 14, pp. 2952-2954 (2012)

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This Letter describes an interferometric technique based on the principle of coherence multiplexing for multichannel, label-free biosensing applications. Multiple biosensors can be interrogated simultaneously with a single spectral-domain, phase-sensitive interferometer by coding the individual sensograms in coherence-multiplexed channels. The experimental results demonstrate the multiplexed quantitative biomolecular interaction of antibodies binding to antigen-coated functionalized biosensor chip surfaces. The described technique also applies to a variety of other distributed and multiplexed sensing applications besides biosensing.

© 2012 Optical Society of America

OCIS Codes
(030.1640) Coherence and statistical optics : Coherence
(060.2370) Fiber optics and optical communications : Fiber optics sensors
(120.0280) Instrumentation, measurement, and metrology : Remote sensing and sensors
(120.3180) Instrumentation, measurement, and metrology : Interferometry
(280.1415) Remote sensing and sensors : Biological sensing and sensors

ToC Category:
Coherence and Statistical Optics

Original Manuscript: January 9, 2012
Revised Manuscript: May 8, 2012
Manuscript Accepted: May 22, 2012
Published: July 13, 2012

Virtual Issues
Vol. 7, Iss. 9 Virtual Journal for Biomedical Optics

Sajal Chirvi, Zexuan Qiang, and Digant P. Davé, "Coherence-multiplexed, label-free biomolecular interaction analysis," Opt. Lett. 37, 2952-2954 (2012)

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  1. J. Homola, Anal. Bioanal. Chem. 377, 528 (2003). [CrossRef]
  2. A. Szabo, L. Stolz, and R. Granzow, Curr. Opin. Struct. Biol. 5, 699 (1995). [CrossRef]
  3. O. Birkert, R. Tünnemann, G. Jung, and G. Gauglitz, Anal. Chem. 74, 834 (2002). [CrossRef]
  4. J. Concepcion, K. Witte, C. Wartchow, S. Choo, D. Yao, H. Persson, W. Henrik, L. Jing, P. Li, B. Heidecker, W. Ma, R. Varma, L. Zhao, D. Perillat, G. Carricato, M. Recknor, K. Du, H. Ho, T. Ellis, J. Gamez, M. Howes, J. Phi-Wilson, S. Lockard, R. Zuk, and H. Tan, Comb. Chem. HTS 12, 791 (2009). [CrossRef]
  5. Y. Fang, A. M. Ferrie, and E. Tran, Methods Mol. Biol. 552, 239 (2009). [CrossRef]
  6. B. T. Cunningham and L. Laing, Expert Rev. Proteomics 3, 271 (2006). [CrossRef]
  7. C. Joo, E. E. Ozkumur, M. Unlu, and J. Boer, Biosens. Bioelectron. 25, 275 (2009). [CrossRef]
  8. C. Joo and J. F. de Boer, Opt. Lett. 32, 2426 (2007). [CrossRef]
  9. D. P. Davé, Methods Mol. Biol. 503, 179 (2009). [CrossRef]

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