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Optics Letters

Optics Letters


  • Editor: Alan E. Willner
  • Vol. 37, Iss. 14 — Jul. 15, 2012
  • pp: 2979–2981

Endogenous contrast blood flow imaging in embryonic hearts using hemoglobin contrast subtraction angiography

Engin Deniz, Stephan Jonas, Mustafa Khokha, and Michael A. Choma  »View Author Affiliations

Optics Letters, Vol. 37, Issue 14, pp. 2979-2981 (2012)

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The genetic basis of congenital heart disease is yet to be defined, and the interactions between the malformed heart and biomechanical cardiac performance remain poorly understood. Functional optical imaging enables detailed biomechanical phenotyping of cardiac dysfunction in small animal models, which in turn enables specific gene-phenotype relationship. We have developed a new microangiography technique based on flow imaging using endogenous hemoglobin contrast enabling in vivo assessment and biomechanical phenotyping of Xenopus tropicalis embryonic heart. We demonstrated that hemoglobin contrast angiography can be used to quantify physiological response to treatment with well-established cardioactive drugs.

© 2012 Optical Society of America

OCIS Codes
(170.1420) Medical optics and biotechnology : Biology
(170.3880) Medical optics and biotechnology : Medical and biological imaging
(170.2655) Medical optics and biotechnology : Functional monitoring and imaging

ToC Category:
Medical Optics and Biotechnology

Original Manuscript: March 28, 2012
Revised Manuscript: June 10, 2012
Manuscript Accepted: June 10, 2012
Published: July 13, 2012

Virtual Issues
Vol. 7, Iss. 9 Virtual Journal for Biomedical Optics

Engin Deniz, Stephan Jonas, Mustafa Khokha, and Michael A. Choma, "Endogenous contrast blood flow imaging in embryonic hearts using hemoglobin contrast subtraction angiography," Opt. Lett. 37, 2979-2981 (2012)

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