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Optics Letters

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  • Editor: Alan E. Willner
  • Vol. 37, Iss. 16 — Aug. 15, 2012
  • pp: 3360–3362

Stokes shift spectroscopy highlights differences of cancerous and normal human tissues

Yang Pu, Wuabo Wang, Yuanlong Yang, and R. R. Alfano  »View Author Affiliations


Optics Letters, Vol. 37, Issue 16, pp. 3360-3362 (2012)
http://dx.doi.org/10.1364/OL.37.003360


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Abstract

The Stokes shift spectroscopy (S3) offers a simpler and better way to recognize spectral fingerprints of fluorophores in complex mixtures. The efficiency of S3 for cancer detection in human tissue was investigated systematically. The alterations of Stokes shift spectra (S3) between cancerous and normal tissues are due to the changes of key fluorophores, e.g., tryptophan and collagen, and can be highlighted using optimized wavelength shift interval. To our knowledge, this is the first time to explicitly disclose how and why S3 is superior in comparison with other conventional spectroscopic techniques.

© 2012 Optical Society of America

OCIS Codes
(170.0170) Medical optics and biotechnology : Medical optics and biotechnology
(170.6510) Medical optics and biotechnology : Spectroscopy, tissue diagnostics
(300.0300) Spectroscopy : Spectroscopy
(300.6170) Spectroscopy : Spectra

ToC Category:
Medical Optics and Biotechnology

History
Original Manuscript: May 15, 2012
Manuscript Accepted: June 25, 2012
Published: August 6, 2012

Virtual Issues
Vol. 7, Iss. 10 Virtual Journal for Biomedical Optics

Citation
Yang Pu, Wuabo Wang, Yuanlong Yang, and R. R. Alfano, "Stokes shift spectroscopy highlights differences of cancerous and normal human tissues," Opt. Lett. 37, 3360-3362 (2012)
http://www.opticsinfobase.org/ol/abstract.cfm?URI=ol-37-16-3360


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References

  1. R. R. Alfano, D. Tata, J. Cordero, P. Tomashefsky, F. Longo, and M. Alfano, IEEE J. Quantum Electron 20, 1507 (1984). [CrossRef]
  2. R. R. Alfano and Y. Yang, IEEE J. Quantum Electron 9, 148 (2003). [CrossRef]
  3. Y. Pu, W. B. Wang, G. C. Tang, and R. R. Alfano, J. Biomed. Opt. 15, 047008 (2010). [CrossRef]
  4. H. J. G. Bloom and W. W. Richardson, Br. J. Cancer 11, 359 (1957). [CrossRef]
  5. G. Fenhalls, D. M. Dent, and M. I. Parker, Br. J. Cancer 81, 1142 (1999). [CrossRef]

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