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Optics Letters

| RAPID, SHORT PUBLICATIONS ON THE LATEST IN OPTICAL DISCOVERIES

  • Editor: Alan E. Willner
  • Vol. 37, Iss. 16 — Aug. 15, 2012
  • pp: 3414–3416

In vivo detection of hemoglobin oxygen saturation and carboxyhemoglobin saturation with multiwavelength photoacoustic microscopy

Zhongjiang Chen, Sihua Yang, and Da Xing  »View Author Affiliations


Optics Letters, Vol. 37, Issue 16, pp. 3414-3416 (2012)
http://dx.doi.org/10.1364/OL.37.003414


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Abstract

A method for noninvasively detecting hemoglobin oxygen saturation (SO2) and carboxyhemoglobin saturation (SCO) in subcutaneous microvasculature with multiwavelength photoacoustic microscopy is presented. Blood samples mixed with different concentrations of carboxyhemoglobin were used to test the feasibility and accuracy of photoacoustic microscopy compared with the blood-gas analyzer. Moreover, fixed-point detection of SO2 and SCO in mouse ear was obtained, and the changes from normoxia to carbon monoxide hypoxia were dynamically monitored in vivo. Experimental results demonstrate that multiwavelength photoacoustic microscopy can detect SO2 and SCO, which has future potential clinical applications.

© 2012 Optical Society of America

OCIS Codes
(110.5120) Imaging systems : Photoacoustic imaging
(170.1470) Medical optics and biotechnology : Blood or tissue constituent monitoring
(170.2655) Medical optics and biotechnology : Functional monitoring and imaging

ToC Category:
Medical Optics and Biotechnology

History
Original Manuscript: March 19, 2012
Revised Manuscript: July 1, 2012
Manuscript Accepted: July 12, 2012
Published: August 8, 2012

Virtual Issues
Vol. 7, Iss. 10 Virtual Journal for Biomedical Optics

Citation
Zhongjiang Chen, Sihua Yang, and Da Xing, "In vivo detection of hemoglobin oxygen saturation and carboxyhemoglobin saturation with multiwavelength photoacoustic microscopy," Opt. Lett. 37, 3414-3416 (2012)
http://www.opticsinfobase.org/ol/abstract.cfm?URI=ol-37-16-3414

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