In this letter, we present experimental results of antibody detection using a biosensor based on photonic bandgap structures, which are interrogated using a power-based readout technique. This interrogation method allows a real-time monitoring of the association process between the antigen probes and the target antibodies, allowing the instantaneous observation of any interaction event between molecules. because etunable lasers and optical spectrum analyzers are avoided for the readout, a drastic reduction of the final cost of the platform is obtained. Furthermore, the performance of the biosensing system is significantly enhanced due to the large number of data values obtained per second.
© 2012 Optical Society of America
Original Manuscript: June 27, 2012
Revised Manuscript: July 26, 2012
Manuscript Accepted: July 26, 2012
Published: August 29, 2012
Vol. 7, Iss. 11 Virtual Journal for Biomedical Optics
J. G. Castelló, V. Toccafondo, J. Escorihuela, M. J. Bañuls, A. Maquieira, and J. García-Rupérez, "Real-time observation of antigen–antibody association using a low-cost biosensing system based on photonic bandgap structures," Opt. Lett. 37, 3684-3686 (2012)