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Er:YAG laser pulse for small-dose splashback-free microjet transdermal drug delivery |
Optics Letters, Vol. 37, Issue 18, pp. 3894-3896 (2012)
http://dx.doi.org/10.1364/OL.37.003894
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Abstract
The microjet injector system accelerates drugs and delivers them without a needle, which is shown to overcome the weaknesses of existing jet injectors. A significant increase in the delivered dose of drugs is reported with multiple pulses of laser beam at lower laser energy than was previously used in a Nd:YAG system. The new injection scheme uses the beam wavelength best absorbable by water at a longer pulse mode for elongated microjet penetration into a skin target. A 2.9 μm Er:YAG laser at 250 μs pulse duration is used for fluorescent staining of guinea pig skin and for injection controllability study. Hydrodynamic theory confirms the nozzle exit jet velocity obtained by the present microjet system.
© 2012 Optical Society of America
OCIS Codes
(140.3440) Lasers and laser optics : Laser-induced breakdown
(170.1870) Medical optics and biotechnology : Dermatology
(230.3990) Optical devices : Micro-optical devices
ToC Category:
Lasers and Laser Optics
History
Original Manuscript: June 14, 2012
Revised Manuscript: August 14, 2012
Manuscript Accepted: August 27, 2012
Published: September 14, 2012
Virtual Issues
Vol. 7, Iss. 11 Virtual Journal for Biomedical Optics
Citation
Mi-ae Park, Hun-jae Jang, Fedir V. Sirotkin, and Jack J. Yoh, "Er:YAG laser pulse for small-dose splashback-free microjet transdermal drug delivery," Opt. Lett. 37, 3894-3896 (2012)
http://www.opticsinfobase.org/ol/abstract.cfm?URI=ol-37-18-3894
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