OSA's Digital Library

Optics Letters

Optics Letters

| RAPID, SHORT PUBLICATIONS ON THE LATEST IN OPTICAL DISCOVERIES

  • Editor: Alan E. Willner
  • Vol. 37, Iss. 19 — Oct. 1, 2012
  • pp: 4005–4007

Fast synchronized dual-wavelength laser speckle imaging system for monitoring hemodynamic changes in a stroke mouse model

Jia Qin, Lei Shi, Suzan Dziennis, Roberto Reif, and Ruikang K. Wang  »View Author Affiliations


Optics Letters, Vol. 37, Issue 19, pp. 4005-4007 (2012)
http://dx.doi.org/10.1364/OL.37.004005


View Full Text Article

Enhanced HTML    Acrobat PDF (306 KB)





Browse Journals / Lookup Meetings

Browse by Journal and Year


   


Lookup Conference Papers

Close Browse Journals / Lookup Meetings

Article Tools

Share
Citations

Abstract

In this Letter, we describe a newly developed synchronized dual-wavelength laser speckle contrast imaging system, which contains two cameras that are synchronously triggered to acquire data. The system can acquire data at a high spatiotemporal resolution (up to 500 Hz for 1000×1000 pixels). A mouse model of stroke is used to demonstrate the capability for imaging the fast changes (within tens of milliseconds) in oxygenated and deoxygenated hemoglobin concentration, and the relative changes in blood flow in the mouse brain, through an intact cranium. This novel imaging technology will enable the study of fast hemodynamics and metabolic changes in vascular diseases.

© 2012 Optical Society of America

OCIS Codes
(110.6150) Imaging systems : Speckle imaging
(170.3880) Medical optics and biotechnology : Medical and biological imaging
(170.2655) Medical optics and biotechnology : Functional monitoring and imaging

ToC Category:
Imaging Systems

History
Original Manuscript: May 31, 2012
Revised Manuscript: August 8, 2012
Manuscript Accepted: August 14, 2012
Published: September 20, 2012

Citation
Jia Qin, Lei Shi, Suzan Dziennis, Roberto Reif, and Ruikang K. Wang, "Fast synchronized dual-wavelength laser speckle imaging system for monitoring hemodynamic changes in a stroke mouse model," Opt. Lett. 37, 4005-4007 (2012)
http://www.opticsinfobase.org/ol/abstract.cfm?URI=ol-37-19-4005


Sort:  Author  |  Year  |  Journal  |  Reset  

References

  1. D. A. Boas and A. K. Dunn, J. Biomed. Opt. 15, 011109 (2010). [CrossRef]
  2. C. Ayata, A. K. Dunn, Y. Gursoy-Ozdemir, Z. H. Huang, D. A. Boas, and M. A. Moskowitz, J. Cereb. Blood Flow Metab. 24, 744 (2004). [CrossRef]
  3. D. A. Boas and A. K. Dunn, J. Biomed. Opt. 15, 011109(2010). [CrossRef]
  4. R. Reif, O. A’Amar, and I. J. Bigio, Appl. Opt. 46, 7317 (2007). [CrossRef]
  5. A. K. Dunn, A. Devor, H. Bolay, M. L. Andermann, M. A. Moskowitz, A. M. Dale, and D. A. Boas, Opt. Lett. 28, 28 (2003). [CrossRef]
  6. J. Qin, R. Reif, Z. W. Zhi, S. Dziennis, and R. K. Wang, Biomed. Opt. Express 3, 455 (2012). [CrossRef]
  7. Z. Luo, Z. Yuan, Y. Pan, and C. Du, Opt. Lett. 34, 1480 (2009). [CrossRef]
  8. Z. J. Yuan, Z. C. Luo, N. D. Volkow, Y. T. Pan, and C. W. Du, Neuroimage 54, 1130 (2011). [CrossRef]
  9. M. B. Bouchard, B. R. Chen, S. A. Burgess, and E. M. C. Hillman, Opt. Express 17, 15670 (2009). [CrossRef]
  10. M. Wolf, U. Wolf, J. H. Choi, V. Toronov, L. A. Paunescu, A. Michalos, and E. Gratton, Psychophysiology 40, 521 (2003). [CrossRef]
  11. V. Kalchenko, N. Madar-Balakirski, I. Meglinski, and A. Harmelin, J. Biophotonics 4, 645 (2011). [CrossRef]
  12. S. A. Carp, G. P. Dai, D. A. Boas, M. A. Franceschini, and Y. R. Kim, Biomed. Opt. Express 1, 553 (2010). [CrossRef]
  13. R. Bandyopadhyay, A. S. Gittings, S. S. Suh, P. K. Dixon, and D. J. Durian, Rev. Sci. Instrum. 76, 093110 (2005). [CrossRef]
  14. C. W. Du, A. P. Koretsky, I. Izrailtyan, and H. Benveniste, J. Cerebr Blood Flow Metab 25, 1078 (2005). [CrossRef]
  15. P. B. Jones, H. K. Shin, D. A. Boas, B. T. Hyman, M. A. Moskowitz, C. Ayata, and A. K. Dunn, J. Biomed. Opt. 13, 044007 (2008). [CrossRef]
  16. W. R. Zhang, I. P. Koerner, R. Noppens, M. Grafe, H. J. Tsai, C. Morisseau, A. Luria, B. D. Hammock, J. R. Falck, and N. J. Alkayed, J. Cereb. Blood Flow Metab. 27, 1931 (2007). [CrossRef]
  17. J. B. Bederson, L. H. Pitts, S. M. Germano, M. C. Nishimura, R. L. Davis, and H. M. Bartkowski, Stroke 17, 1304(1986). [CrossRef]
  18. G. J. Del Zoppo, B. R. Copeland, L. A. Harker, T. A. Waltz, J. Zyroff, S. R. Hanson, and E. Battenberg, Stroke 17, 1254 (1986). [CrossRef]
  19. J. Krejza, J. Fryc, M. Owlasiuk, M. Huba, R. J. Bert, and Z. Mariak, Clin. Imaging 25, 90 (2001). [CrossRef]

Cited By

Alert me when this paper is cited

OSA is able to provide readers links to articles that cite this paper by participating in CrossRef's Cited-By Linking service. CrossRef includes content from more than 3000 publishers and societies. In addition to listing OSA journal articles that cite this paper, citing articles from other participating publishers will also be listed.

Figures

Fig. 1. Fig. 2.
 

« Previous Article  |  Next Article »

OSA is a member of CrossRef.

CrossCheck Deposited