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Optics Letters

Optics Letters


  • Editor: Alan E. Willner
  • Vol. 37, Iss. 19 — Oct. 1, 2012
  • pp: 4005–4007

Fast synchronized dual-wavelength laser speckle imaging system for monitoring hemodynamic changes in a stroke mouse model

Jia Qin, Lei Shi, Suzan Dziennis, Roberto Reif, and Ruikang K. Wang  »View Author Affiliations

Optics Letters, Vol. 37, Issue 19, pp. 4005-4007 (2012)

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In this Letter, we describe a newly developed synchronized dual-wavelength laser speckle contrast imaging system, which contains two cameras that are synchronously triggered to acquire data. The system can acquire data at a high spatiotemporal resolution (up to 500 Hz for 1000×1000 pixels). A mouse model of stroke is used to demonstrate the capability for imaging the fast changes (within tens of milliseconds) in oxygenated and deoxygenated hemoglobin concentration, and the relative changes in blood flow in the mouse brain, through an intact cranium. This novel imaging technology will enable the study of fast hemodynamics and metabolic changes in vascular diseases.

© 2012 Optical Society of America

OCIS Codes
(110.6150) Imaging systems : Speckle imaging
(170.3880) Medical optics and biotechnology : Medical and biological imaging
(170.2655) Medical optics and biotechnology : Functional monitoring and imaging

ToC Category:
Imaging Systems

Original Manuscript: May 31, 2012
Revised Manuscript: August 8, 2012
Manuscript Accepted: August 14, 2012
Published: September 20, 2012

Jia Qin, Lei Shi, Suzan Dziennis, Roberto Reif, and Ruikang K. Wang, "Fast synchronized dual-wavelength laser speckle imaging system for monitoring hemodynamic changes in a stroke mouse model," Opt. Lett. 37, 4005-4007 (2012)

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