OSA's Digital Library

Optics Letters

Optics Letters


  • Editor: Alan E. Willner
  • Vol. 37, Iss. 20 — Oct. 15, 2012
  • pp: 4263–4265

Miniaturized all-optical photoacoustic microscopy based on microelectromechanical systems mirror scanning

Sung-Liang Chen, Zhixing Xie, Tao Ling, L. Jay Guo, Xunbin Wei, and Xueding Wang  »View Author Affiliations

Optics Letters, Vol. 37, Issue 20, pp. 4263-4265 (2012)

View Full Text Article

Enhanced HTML    Acrobat PDF (413 KB)

Browse Journals / Lookup Meetings

Browse by Journal and Year


Lookup Conference Papers

Close Browse Journals / Lookup Meetings

Article Tools



Achieving photoacoustic microscopic imaging through a miniaturized scanning head is a crucial step toward high-resolution photoacoustic endoscopy. In this work, we have developed a miniaturized probe head using a microelectromechanical systems (MEMS) based mirror for raster scan of the laser beam and our newly developed super broad bandwidth microring resonator based ultrasound detector for photoacoustic signal detection. Through this all-optical design, which offers unique advantages for endoscopic applications, this system is capable of three-dimensional (3D) imaging with high resolution of 17.5 μm in lateral direction and 20 μm in axial direction at a distance of 3.7 mm. After the performance of this system was validated through the experiments on printed grids and a resolution test target, microscopic imaging of the 3D microvasculatures in canine bladders was also conducted successfully, demonstrating the potential of novel photoacoustic endoscopic in future clinical management of bladder cancer.

© 2012 Optical Society of America

OCIS Codes
(170.3880) Medical optics and biotechnology : Medical and biological imaging
(170.5120) Medical optics and biotechnology : Photoacoustic imaging
(180.5810) Microscopy : Scanning microscopy

ToC Category:
Medical Optics and Biotechnology

Original Manuscript: August 6, 2012
Manuscript Accepted: August 31, 2012
Published: October 11, 2012

Sung-Liang Chen, Zhixing Xie, Tao Ling, L. Jay Guo, Xunbin Wei, and Xueding Wang, "Miniaturized all-optical photoacoustic microscopy based on microelectromechanical systems mirror scanning," Opt. Lett. 37, 4263-4265 (2012)

Sort:  Author  |  Year  |  Journal  |  Reset  


  1. A. Jemal, R. Siegel, J. Xu, and E. Ward, CA-Cancer J. Clin. 60, 277 (2010). [CrossRef]
  2. E. B. C. Avritscher, C. D. Cooksley, H. B. Grossman, A. L. Sabichi, L. Hamblin, C. P. Dinney, and L. S. Elting, Urology 68, 549 (2006). [CrossRef]
  3. M. F. Botteman, C. L. Pashos, A. Redaelli, B. Laskin, and R. Hauser, Pharmacoeconomics 21, 1315 (2003).
  4. L. V. Wang, ed., in Photoacoustic Imaging and Spectroscopy (Taylor & Francis/CRC Press, 2009).
  5. Y.-K. Zee, J. P. B. O’Connor, G. J. M. Parker, A. Jackson, A. R. Clamp, M. B. Taylor, N. W. Clarke, and G. C. Jayson, Nat. Rev. Urol. 7, 69 (2010). [CrossRef]
  6. B. H. Bochner, R. J. Cote, N. Weidner, S. Groshen, S.-C. Chen, D. G. Skinner, and P. W. Nichols, J. Natl. Cancer Inst. 87, 1603 (1995).
  7. J.-M. Yang, K. Maslov, H.-C. Yang, Q. Zhou, K. K. Shung, and L. V. Wang, Opt. Lett. 34, 1591 (2009). [CrossRef]
  8. Y. Yuan, S. Yang, and D. Xing, Opt. Lett. 35, 2266 (2010). [CrossRef]
  9. L. Xi, J. Sun, Y. Zhu, L. Wu, H. Xie, and H. Jiang, Biomed. Opt. Express 1, 1278 (2010). [CrossRef]
  10. S.-L. Chen, T. Ling, H. W. Baac, and L. J. Guo, Proc. SPIE 7899, 78992T (2011).
  11. J. Yao, C.-H. Huang, L. Wang, J.-M. Yang, L. Gao, K. I. Maslov, J. Zou, and L. V. Wang, J. Biomed. Opt. 17, 080505, (2012). [CrossRef]
  12. Z. Xie, S.-L. Chen, T. Ling, L. J. Guo, P. L. Carson, and X. Wang, Opt. Express 19, 9027 (2011). [CrossRef]
  13. C.-Y. Chao, S. Ashkenazi, S.-W. Huang, M. O’Donnell, and L. J. Guo, IEEE Trans. Ultrason. Ferroelectr. Freq. Control 54, 957 (2007). [CrossRef]

Cited By

Alert me when this paper is cited

OSA is able to provide readers links to articles that cite this paper by participating in CrossRef's Cited-By Linking service. CrossRef includes content from more than 3000 publishers and societies. In addition to listing OSA journal articles that cite this paper, citing articles from other participating publishers will also be listed.


Fig. 1. Fig. 2. Fig. 3.

« Previous Article  |  Next Article »

OSA is a member of CrossRef.

CrossCheck Deposited