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Optically absorbing nanoparticle mediated cell membrane permeabilization |
Optics Letters, Vol. 37, Issue 21, pp. 4474-4476 (2012)
http://dx.doi.org/10.1364/OL.37.004474
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Abstract
Membrane permeabilization is imperative for gene and drug delivery systems, along with other cell manipulation methods, since the average eukaryotic cell membrane is not permeable to polar and large nonpolar molecules. Antibody conjugated optically absorbing gold nanospheres are targeted to the cell membrane of T47D breast cancer cell line and irradiated with 5 ns pulse, 20 Hz, 532 nm light to increase membrane permeability. Up to 90% permeabilization with less than 6% death is reported at radiant exposures up to 10 times lower than those of other comparable studies.
© 2012 Optical Society of America
OCIS Codes
(170.1530) Medical optics and biotechnology : Cell analysis
(170.1610) Medical optics and biotechnology : Clinical applications
ToC Category:
Medical Optics and Biotechnology
History
Original Manuscript: July 9, 2012
Revised Manuscript: September 1, 2012
Manuscript Accepted: September 19, 2012
Published: October 25, 2012
Virtual Issues
Vol. 7, Iss. 12 Virtual Journal for Biomedical Optics
Citation
Kiran Bhattacharyya, Smit Mehta, and John Viator, "Optically absorbing nanoparticle mediated cell membrane permeabilization," Opt. Lett. 37, 4474-4476 (2012)
http://www.opticsinfobase.org/ol/abstract.cfm?URI=ol-37-21-4474
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