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Nonlinear photoacoustic signal increase from endocytosis of gold nanoparticles |
Optics Letters, Vol. 37, Issue 22, pp. 4708-4710 (2012)
http://dx.doi.org/10.1364/OL.37.004708
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Abstract
Nonlinear photoacoustic effects, rarely seen in biomedical photoacoustic imaging of tissues, can manifest themselves strongly when plasmonic nanoparticles are used as imaging contrast agents. Specifically, nonlinear behavior of photoacoustic signal with modest laser fluences can occur when nanoparticles undergo cellular endocytosis and aggregation leading to thermal coupling and subsequent localized temperature enhancement. Our study demonstrated this effect using in vitro tissue models containing cells. While the photoacoustic signal amplitude was linearly proportional to the cell/nanoparticle concentration, the photoacoustic signal increased nonlinearly as the laser fluence increased. Our results, therefore, suggest that the nonlinear effects can be exploited in molecular/cellular photoacoustic imaging.
© 2012 Optical Society of America
OCIS Codes
(110.5120) Imaging systems : Photoacoustic imaging
(170.3880) Medical optics and biotechnology : Medical and biological imaging
(110.5125) Imaging systems : Photoacoustics
ToC Category:
Medical Optics and Biotechnology
History
Original Manuscript: July 20, 2012
Revised Manuscript: October 2, 2012
Manuscript Accepted: October 5, 2012
Published: November 12, 2012
Virtual Issues
Vol. 7, Iss. 12 Virtual Journal for Biomedical Optics
Citation
Seung Yun Nam, Laura M. Ricles, Laura J. Suggs, and Stanislav Y. Emelianov, "Nonlinear photoacoustic signal increase from endocytosis of gold nanoparticles," Opt. Lett. 37, 4708-4710 (2012)
http://www.opticsinfobase.org/ol/abstract.cfm?URI=ol-37-22-4708
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