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Direct Monte Carlo computation of time-resolved fluorescence in heterogeneous turbid media |
Optics Letters, Vol. 37, Issue 22, pp. 4783-4785 (2012)
http://dx.doi.org/10.1364/OL.37.004783
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Abstract
We show that a multiexponential model for time-resolved fluorescence allows the use of an absorption-perturbation Monte Carlo (MC) approach based on stored photon path histories. This enables the rapid fitting of fluorescence yield, lifetimes, and background tissue absorptions in complex heterogeneous media within a few seconds, without the need for temporal convolutions or MC recalculation of photon path lengths. We validate this method using simulations with both a slab and a heterogeneous model of the mouse head.
© 2012 Optical Society of America
OCIS Codes
(170.3880) Medical optics and biotechnology : Medical and biological imaging
(170.6920) Medical optics and biotechnology : Time-resolved imaging
(170.6960) Medical optics and biotechnology : Tomography
ToC Category:
Medical Optics and Biotechnology
History
Original Manuscript: August 2, 2012
Revised Manuscript: September 25, 2012
Manuscript Accepted: October 16, 2012
Published: November 14, 2012
Virtual Issues
Vol. 7, Iss. 12 Virtual Journal for Biomedical Optics
Citation
Anand T. N. Kumar, "Direct Monte Carlo computation of time-resolved fluorescence in heterogeneous turbid media," Opt. Lett. 37, 4783-4785 (2012)
http://www.opticsinfobase.org/ol/abstract.cfm?URI=ol-37-22-4783
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