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Optics Letters

Optics Letters


  • Editor: Alan E. Willner
  • Vol. 37, Iss. 23 — Dec. 1, 2012
  • pp: 4841–4843

Three-dimensional multiwaveguide probe array for light delivery to distributed brain circuits

Anthony N. Zorzos, Jorg Scholvin, Edward S. Boyden, and Clifton G. Fonstad  »View Author Affiliations

Optics Letters, Vol. 37, Issue 23, pp. 4841-4843 (2012)

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To deliver light to the brain for neuroscientific and neuroengineering applications like optogenetics, in which light is used to activate or silence neurons expressing specific photosensitive proteins, optical fibers are commonly used. However, an optical fiber is limited to delivering light to a single target within the 3D structure of the brain. Here, we describe the design and fabrication of an array of thin microwaveguides, which terminates at a three-dimensionally distributed set of points, appropriate for delivering light to targets distributed in a 3D pattern throughout the brain.

© 2012 Optical Society of America

OCIS Codes
(130.3120) Integrated optics : Integrated optics devices
(170.0170) Medical optics and biotechnology : Medical optics and biotechnology
(230.3990) Optical devices : Micro-optical devices
(230.7370) Optical devices : Waveguides
(130.2755) Integrated optics : Glass waveguides
(130.3990) Integrated optics : Micro-optical devices

ToC Category:
Medical Optics and Biotechnology

Original Manuscript: August 3, 2012
Revised Manuscript: October 10, 2012
Manuscript Accepted: October 18, 2012
Published: November 20, 2012

Virtual Issues
Vol. 8, Iss. 1 Virtual Journal for Biomedical Optics

Anthony N. Zorzos, Jorg Scholvin, Edward S. Boyden, and Clifton G. Fonstad, "Three-dimensional multiwaveguide probe array for light delivery to distributed brain circuits," Opt. Lett. 37, 4841-4843 (2012)

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  1. E. S. Boyden, F. Zhang, E. Bamberg, G. Nagel, and K. Deisseroth, Nat. Neurosci. 8, 1263 (2005). [CrossRef]
  2. X. Han and E. S. Boyden, PLoS ONE 2, e299 (2007). [CrossRef]
  3. F. Zhang, L. P. Wang, M. Brauner, J. F. Liewald, K. Kay, N. Watzke, P. G. Wood, E. Bamberg, G. Nagel, A. Gottschalk, and K. Deisseroth, Nature 446, 633 (2007). [CrossRef]
  4. B. Y. Chow, X. Han, A. S. Dobry, X. Qian, A. S. Chuong, M. Li, M. A. Henninger, G. M. Belfort, Y. Lin, P. E. Monahan, and E. S. Boyden, Nature 463, 98 (2010). [CrossRef]
  5. X. Han, B. Y. Chow, H. Zhou, N. C. Klapoetke, A. Chuong, R. Rajimehr, A. Yang, M. V. Baratta, J. Winkle, R. Desimone, and E. S. Boyden, Front. Syst. Neurosci. 5, 18 (2011). [CrossRef]
  6. T. V. F. Abaya, M. Diwekar, S. Blair, P. Tathireddy, L. Rieth, G. A. Clark, and F. Solzbacher, Proc. SPIE 8207, 82075M (2012). [CrossRef]
  7. M. Im, I. J. Cho, F. Wu, K. D. Wise, and E. Yoon, 2011 IEEE 24th International Conference on Micro Electro Mechanical Systems (IEEE, 2011), pp. 1051–1054.
  8. S. Royer, B. V. Zemelman, M. Barbic, A. Losonczy, G. Buzsaki, and J. C. Magee, Eur. J. Neurosci. 31, 2279(2010). [CrossRef]
  9. E. Stark, T. Koos, and G. Buzsaki, J. Neurophysiol. 108, 349 (2012). [CrossRef]
  10. A. N. Zorzos, E. S. Boyden, and C. G. Fonstad, Opt. Lett. 35, 4133 (2010). [CrossRef]

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