Expand this Topic clickable element to expand a topic
Skip to content
Optica Publishing Group

Integrated multimodal endomicroscopy platform for simultaneous en face optical coherence and two-photon fluorescence imaging

Not Accessible

Your library or personal account may give you access

Abstract

We report an all-fiber-optic scanning, multimodal endomicroscope capable of simultaneous optical coherence tomography (OCT) and two-photon fluorescence (TPF) imaging. Both imaging modalities share the same miniature fiber-optic scanning endomicroscope, which consists of a double-clad fiber with a core operating in single mode at both the OCT (1310 nm) and two-photon excitation (1550 nm) wavelengths, a piezoelectric two-dimensional fiber-optic beam scanner, and a miniature aspherical compound lens suitable for simultaneous acquisition of en face OCT and TPF images. A fiber-optic wavelength division multiplexer was employed in the integrated platform to combine the low coherence OCT light source and the femtosecond two-photon excitation laser into the same optical path. Preliminary imaging results of cell cultures and mouse tissue ex vivo demonstrate the feasibility of simultaneous real-time OCT and TPF imaging in a scanning endomicroscopy setting for the first time.

©2012 Optical Society of America

Full Article  |  PDF Article
More Like This
Compensation-free, all-fiber-optic, two-photon endomicroscopy at 1.55 μm

Kartikeya Murari, Yuying Zhang, Shenping Li, Yongping Chen, Ming-Jun Li, and Xingde Li
Opt. Lett. 36(7) 1299-1301 (2011)

An all-fiber-optic endoscopy platform for simultaneous OCT and fluorescence imaging

Jessica Mavadia, Jiefeng Xi, Yongping Chen, and Xingde Li
Biomed. Opt. Express 3(11) 2851-2859 (2012)

Scanning fiber-optic nonlinear endomicroscopy with miniature aspherical compound lens and multimode fiber collector

Yicong Wu, Jiefeng Xi, Michael J. Cobb, and Xingde Li
Opt. Lett. 34(7) 953-955 (2009)

Cited By

You do not have subscription access to this journal. Cited by links are available to subscribers only. You may subscribe either as an Optica member, or as an authorized user of your institution.

Contact your librarian or system administrator
or
Login to access Optica Member Subscription

Figures (3)

You do not have subscription access to this journal. Figure files are available to subscribers only. You may subscribe either as an Optica member, or as an authorized user of your institution.

Contact your librarian or system administrator
or
Login to access Optica Member Subscription

Select as filters


Select Topics Cancel
© Copyright 2024 | Optica Publishing Group. All Rights Reserved