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Optics Letters

Optics Letters


  • Editor: Alan E. Willner
  • Vol. 37, Iss. 4 — Feb. 15, 2012
  • pp: 614–616

In vivo optical neural recording using fiber-based surface plasmon resonance

Shin Ae Kim, Sung June Kim, Hyowon Moon, and Sang Beom Jun  »View Author Affiliations

Optics Letters, Vol. 37, Issue 4, pp. 614-616 (2012)

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We propose an intrinsic optical method for in vivo neural recording using optic fiber-based surface plasmon resonance (SPR) phenomena. The fiber-based SPR method is electrical artifact free, labeling free, and feasible for a portable system compared with conventional in vivo neural recording systems. We simultaneously detected SPR signals and electrical neural activity from the rat somatosensory cortex evoked by electrical stimulation on the forepaw. Pharmacological analysis using a voltage-gated sodium channel blocker confirmed the neural origins of the optical signals. This fiber-based SPR system promises the enhanced ability to record in vivo neural activity for the investigation of neurons and their networks.

© 2012 Optical Society of America

OCIS Codes
(060.2370) Fiber optics and optical communications : Fiber optics sensors
(240.0310) Optics at surfaces : Thin films
(240.6680) Optics at surfaces : Surface plasmons
(280.1415) Remote sensing and sensors : Biological sensing and sensors

ToC Category:
Optics at Surfaces

Original Manuscript: October 31, 2011
Revised Manuscript: December 18, 2011
Manuscript Accepted: December 24, 2011
Published: February 10, 2012

Virtual Issues
Vol. 7, Iss. 4 Virtual Journal for Biomedical Optics

Shin Ae Kim, Sung June Kim, Hyowon Moon, and Sang Beom Jun, "In vivo optical neural recording using fiber-based surface plasmon resonance," Opt. Lett. 37, 614-616 (2012)

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