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Optics Letters

Optics Letters


  • Editor: Alan E. Willner
  • Vol. 37, Iss. 4 — Feb. 15, 2012
  • pp: 644–646

High-contrast mapping of basal cell carcinomas

Anna N. Yaroslavsky, Rakesh Patel, Elena Salomatina, Chunqiang Li, Charles Lin, Munir Al-Arashi, and Victor Neel  »View Author Affiliations

Optics Letters, Vol. 37, Issue 4, pp. 644-646 (2012)

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Because of low optical contrast in the visible spectral range, accurate detection of basal cell carcinomas (BCC) remains a challenging problem. In this letter, we experimentally demonstrate that reflectance confocal imaging in the vicinity of 1300 nm can be used for the detection of BCC without exogenous contrast agents. We present high-contrast reflectance confocal images of thick fresh skin tissues with clearly delineated cancer and discuss possible reasons for causing decreased scattering of BCC. Comparison with histopathology confirms that tumors scatter less and exhibit lower pixel values in the images, as compared to benign skin structures. The results demonstrate the feasibility of real-time noninvasive detection of BCC using intrinsic differences in scattering between tumors and normal skin.

© 2012 Optical Society of America

OCIS Codes
(170.0170) Medical optics and biotechnology : Medical optics and biotechnology
(170.1790) Medical optics and biotechnology : Confocal microscopy
(170.1870) Medical optics and biotechnology : Dermatology
(170.4730) Medical optics and biotechnology : Optical pathology
(290.1350) Scattering : Backscattering
(290.4020) Scattering : Mie theory

ToC Category:
Medical Optics and Biotechnology

Original Manuscript: July 26, 2011
Revised Manuscript: December 17, 2011
Manuscript Accepted: December 24, 2011
Published: February 13, 2012

Virtual Issues
Vol. 7, Iss. 4 Virtual Journal for Biomedical Optics

Anna N. Yaroslavsky, Rakesh Patel, Elena Salomatina, Chunqiang Li, Charles Lin, Munir Al-Arashi, and Victor Neel, "High-contrast mapping of basal cell carcinomas," Opt. Lett. 37, 644-646 (2012)

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