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Optics Letters

Optics Letters


  • Editor: Alan E. Willner
  • Vol. 37, Iss. 5 — Mar. 1, 2012
  • pp: 981–983

Optical detection of indocyanine green encapsulated biocompatible poly (lactic-co-glycolic) acid nanoparticles with photothermal optical coherence tomography

Hrebesh M. Subhash, Hui Xie, Jeffrey W. Smith, and Owen J. T. McCarty  »View Author Affiliations

Optics Letters, Vol. 37, Issue 5, pp. 981-983 (2012)

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We describe a functional imaging paradigm that uses photothermal optical coherence tomography (PT-OCT) to detect indocyanine green (ICG)-encapsulated biocompatible poly(lactic-co-glycolic) acid (PLGA) nanoparticles embedded in highly scattering tissue phantoms with high resolution and sensitivity. The ICG-loaded PLGA nanoparticles were fabricated using a modified emulsification solvent diffusion method. With a 20 kHz axial scan rate, PT-OCT based on spectral-domain interferometric configuration at 1310 nm was used to detect phase changes induced by a 808 nm photothermal excitation of ICG-encapsulated PLGA nanoparticles. An algorithm based on Fourier transform analysis of differential phase of the spectral interferogram was developed for detecting the depth resolved localized photothermal signal. Excellent contrast difference was observed with PT-OCT between phantoms containing different concentrations of ICG-encapsulated PLGA nanoparticles. This technique has the potential to provide simultaneous structural and molecular-targeted imaging with excellent signal-to-noise for various clinical applications.

© 2012 Optical Society of America

OCIS Codes
(110.4500) Imaging systems : Optical coherence tomography
(120.5050) Instrumentation, measurement, and metrology : Phase measurement
(170.6930) Medical optics and biotechnology : Tissue
(190.4870) Nonlinear optics : Photothermal effects
(160.4236) Materials : Nanomaterials

ToC Category:
Medical Optics and Biotechnology

Original Manuscript: November 2, 2011
Revised Manuscript: January 13, 2012
Manuscript Accepted: January 19, 2012
Published: March 1, 2012

Virtual Issues
Vol. 7, Iss. 5 Virtual Journal for Biomedical Optics

Hrebesh M. Subhash, Hui Xie, Jeffrey W. Smith, and Owen J. T. McCarty, "Optical detection of indocyanine green encapsulated biocompatible poly (lactic-co-glycolic) acid nanoparticles with photothermal optical coherence tomography," Opt. Lett. 37, 981-983 (2012)

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