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Optics Letters

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  • Editor: Alan E. Willner
  • Vol. 37, Iss. 6 — Mar. 15, 2012
  • pp: 1061–1063

Mueller matrix polarimetry for improved liver fibrosis diagnosis

Matthieu Dubreuil, Philippe Babilotte, Loïc Martin, David Sevrain, Sylvain Rivet, Yann Le Grand, Guy Le Brun, Bruno Turlin, and Bernard Le Jeune  »View Author Affiliations


Optics Letters, Vol. 37, Issue 6, pp. 1061-1063 (2012)
http://dx.doi.org/10.1364/OL.37.001061


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Abstract

An experimental Mueller matrix polarimeter is used to quantify human liver fibrosis by measuring retardance and depolarization of thin biopsies. The former parameter is sensitive to fibrillar collagen, the latter is specifically sensitive to fibrillar collagen around blood vessels, which is not significant for liver fibrosis diagnosis. By using depolarization like a filter, retardance distribution enables distinguishing between disease stages and limits the high degree of observer discrepancy.

© 2012 Optical Society of America

OCIS Codes
(120.2130) Instrumentation, measurement, and metrology : Ellipsometry and polarimetry
(120.3930) Instrumentation, measurement, and metrology : Metrological instrumentation
(120.5410) Instrumentation, measurement, and metrology : Polarimetry
(170.3890) Medical optics and biotechnology : Medical optics instrumentation
(170.4580) Medical optics and biotechnology : Optical diagnostics for medicine
(170.6935) Medical optics and biotechnology : Tissue characterization

ToC Category:
Instrumentation, Measurement, and Metrology

History
Original Manuscript: November 8, 2011
Revised Manuscript: January 6, 2012
Manuscript Accepted: January 17, 2012
Published: March 12, 2012

Virtual Issues
Vol. 7, Iss. 5 Virtual Journal for Biomedical Optics

Citation
Matthieu Dubreuil, Philippe Babilotte, Loïc Martin, David Sevrain, Sylvain Rivet, Yann Le Grand, Guy Le Brun, Bruno Turlin, and Bernard Le Jeune, "Mueller matrix polarimetry for improved liver fibrosis diagnosis," Opt. Lett. 37, 1061-1063 (2012)
http://www.opticsinfobase.org/ol/abstract.cfm?URI=ol-37-6-1061


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