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Intravascular photoacoustic imaging of lipid in atherosclerotic plaques in the presence of luminal blood |
Optics Letters, Vol. 37, Issue 7, pp. 1244-1246 (2012)
http://dx.doi.org/10.1364/OL.37.001244
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Abstract
Intravascular photoacoustic (IVPA) imaging can characterize atherosclerotic plaque composition on the basis of the optical absorption contrast between different tissue types. Given the high optical absorption of lipid at 1720 nm wavelength, an atherosclerotic rabbit aorta was imaged at this wavelength ex vivo using an integrated intravascular ultrasound (IVUS) and IVPA imaging catheter in the presence of luminal blood. Strong optical absorption of lipid combined with low background signal from other tissues provides a high-contrast, depth-resolved IVPA image of lipid. The ability to image lipid at a single wavelength without removing luminal blood suggests that in vivo detection of lipid in atherosclerotic plaques using combined IVUS/IVPA imaging is possible.
© 2012 Optical Society of America
OCIS Codes
(110.5120) Imaging systems : Photoacoustic imaging
(170.2150) Medical optics and biotechnology : Endoscopic imaging
(170.7170) Medical optics and biotechnology : Ultrasound
(170.6935) Medical optics and biotechnology : Tissue characterization
ToC Category:
Medical Optics and Biotechnology
History
Original Manuscript: July 26, 2011
Revised Manuscript: February 10, 2012
Manuscript Accepted: February 14, 2012
Published: March 28, 2012
Virtual Issues
Vol. 7, Iss. 6 Virtual Journal for Biomedical Optics
Citation
Bo Wang, Andrei Karpiouk, Doug Yeager, James Amirian, Silvio Litovsky, Richard Smalling, and Stanislav Emelianov, "Intravascular photoacoustic imaging of lipid in atherosclerotic plaques in the presence of luminal blood," Opt. Lett. 37, 1244-1246 (2012)
http://www.opticsinfobase.org/ol/abstract.cfm?URI=ol-37-7-1244
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