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Optics Letters

Optics Letters


  • Editor: Alan E. Willner
  • Vol. 37, Iss. 8 — Apr. 15, 2012
  • pp: 1388–1390

Cerebral blood flow imaged with ultrahigh-resolution optical coherence angiography and Doppler tomography

Hugang Ren, Congwu Du, and Yingtian Pan  »View Author Affiliations

Optics Letters, Vol. 37, Issue 8, pp. 1388-1390 (2012)

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Speckle contrast based optical coherence angiography (OCA) and optical coherence Doppler tomography (ODT) have been applied to image cerebral blood flow previously. However, the contrast mechanisms of these two methods are not fully studied. Here, we present both flow phantom and in vivo animal experiments using ultrahigh-resolution OCA (μOCA) and ODT (μODT) to investigate the flow sensitivity differences between these two methods. Our results show that the high sensitivity of μOCA for visualizing minute vasculature (e.g., slow capillary beds) is due to the enhancement by random Brownian motion of scatterers (e.g., red and white blood cells) within the vessels; whereas, μODT permits detection of directional flow below the Brownian motion regime (e.g., laser-induced microischemia) and is, therefore, more suitable for brain functional imaging.

© 2012 Optical Society of America

OCIS Codes
(110.4500) Imaging systems : Optical coherence tomography
(170.0110) Medical optics and biotechnology : Imaging systems
(170.2655) Medical optics and biotechnology : Functional monitoring and imaging

ToC Category:
Imaging Systems

Original Manuscript: November 30, 2011
Revised Manuscript: February 7, 2012
Manuscript Accepted: February 10, 2012
Published: April 13, 2012

Virtual Issues
Vol. 7, Iss. 6 Virtual Journal for Biomedical Optics

Hugang Ren, Congwu Du, and Yingtian Pan, "Cerebral blood flow imaged with ultrahigh-resolution optical coherence angiography and Doppler tomography," Opt. Lett. 37, 1388-1390 (2012)

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