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Optics Letters

Optics Letters

| RAPID, SHORT PUBLICATIONS ON THE LATEST IN OPTICAL DISCOVERIES

  • Editor: Alan E. Willner
  • Vol. 38, Iss. 11 — Jun. 1, 2013
  • pp: 1841–1843

Overlap time-gating approach for improving time-domain diffuse fluorescence tomography based on the IRF-calibrated Born normalization

Jiao Li, Xi Yi, Xin Wang, Yiming Lu, Limin Zhang, Huijuan Zhao, and Feng Gao  »View Author Affiliations


Optics Letters, Vol. 38, Issue 11, pp. 1841-1843 (2013)
http://dx.doi.org/10.1364/OL.38.001841


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Abstract

Diffuse fluorescence tomography (DFT) methods using the full time-resolved (TR) data have been demonstrated to substantially improve the spatial resolution and quantitative accuracy of reconstructed images. However, these methods usually suffer from low practical feasibility because of the influence of the system impulse response function (IRF) and the trade-off between the used data time-resolution and the required signal-to-noise ratio (SNR). We present a full TR approach that combines an IRF-calibrated full TR Born normalization and an overlap-delaying time-gate scheme for attaining high SNR without sacrificing the TR information content. The approach is validated with full TR data from phantom experiments for its better performances in the spatial resolution and reconstruction fidelity compared to the traditional DFT methods.

© 2013 Optical Society of America

OCIS Codes
(170.3010) Medical optics and biotechnology : Image reconstruction techniques
(170.3880) Medical optics and biotechnology : Medical and biological imaging
(170.5280) Medical optics and biotechnology : Photon migration
(170.6960) Medical optics and biotechnology : Tomography

ToC Category:
Medical Optics and Biotechnology

History
Original Manuscript: March 18, 2013
Revised Manuscript: April 29, 2013
Manuscript Accepted: April 29, 2013
Published: May 21, 2013

Virtual Issues
Vol. 8, Iss. 7 Virtual Journal for Biomedical Optics

Citation
Jiao Li, Xi Yi, Xin Wang, Yiming Lu, Limin Zhang, Huijuan Zhao, and Feng Gao, "Overlap time-gating approach for improving time-domain diffuse fluorescence tomography based on the IRF-calibrated Born normalization," Opt. Lett. 38, 1841-1843 (2013)
http://www.opticsinfobase.org/ol/abstract.cfm?URI=ol-38-11-1841

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