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Optics Letters

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  • Editor: Alan E. Willner
  • Vol. 38, Iss. 12 — Jun. 15, 2013
  • pp: 2038–2040

Resolution below the point spread function for diffuse optical imaging using fluorescence lifetime multiplexing

William L. Rice, Steven Hou, and Anand T. N. Kumar  »View Author Affiliations


Optics Letters, Vol. 38, Issue 12, pp. 2038-2040 (2013)
http://dx.doi.org/10.1364/OL.38.002038


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Abstract

We show that asymptotic lifetime-based fluorescence tomography can localize multiple-lifetime targets separated well below the diffuse point spread function of a turbid medium. This is made possible due to a complete diagonalization of the time domain forward problem in the asymptotic limit. We also show that continuous wave or direct time gate approaches to fluorescence tomography are unable to achieve this separation, indicating the unique advantage of a decay-amplitude-based approach for tomographic lifetime multiplexing with time domain data.

© 2013 Optical Society of America

OCIS Codes
(170.3880) Medical optics and biotechnology : Medical and biological imaging
(170.6920) Medical optics and biotechnology : Time-resolved imaging
(170.6960) Medical optics and biotechnology : Tomography

ToC Category:
Medical Optics and Biotechnology

History
Original Manuscript: April 12, 2013
Manuscript Accepted: May 8, 2013
Published: June 4, 2013

Virtual Issues
Vol. 8, Iss. 7 Virtual Journal for Biomedical Optics

Citation
William L. Rice, Steven Hou, and Anand T. N. Kumar, "Resolution below the point spread function for diffuse optical imaging using fluorescence lifetime multiplexing," Opt. Lett. 38, 2038-2040 (2013)
http://www.opticsinfobase.org/ol/abstract.cfm?URI=ol-38-12-2038


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